TY - JOUR
T1 - Dose-dependent effects of lifestyle interventions on blood lipid levels
T2 - Results from the PREMIER trial
AU - Dudum, Ramzi
AU - Juraschek, Stephen P.
AU - Appel, Lawrence J.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10
Y1 - 2019/10
N2 - Objective: To assess the effects of comprehensive lifestyle modification on low-density lipoprotein cholesterol (LDL-C) levels and whether greater participation in counseling sessions was associated with greater LDL-C reductions. Methods: Multicenter trial of Pre- or Stage 1 hypertensive adults randomized to: (1)Advice alone, (2)‘Established’ lifestyle intervention implementing physical activity, sodium reduction, and weight loss, if overweight, or (3)‘Established + DASH’ lifestyle intervention with DASH diet counseling. Both intervention groups received behavioral counseling. We used generalized estimating equations to model the intervention's effects on lipid outcomes. Analyses of number of sessions and lipids were adjusted for demographics and medical history. Results: Among 756 participants (mean age 49.7, 63.2% women, 34.7% black), both lifestyle interventions reduced LDL-C, triglycerides, and total cholesterol (TC) at six months. Compared to the ‘Advice’ arm, net mean lipid changes in the Established group were: LDL-C of -5.6 mg/dL (p=0.001) and TC of -7.3 mg/dL (p<0.001). Similarly, changes in the ‘Established + DASH’ group were: LDL-C of -4.0 mg/dL (p=0.03) and TC of -5.7 mg/dL (p=0.006). In dose-response analyses, for every 10-session increase, LDL-C changed by -6.2 mg/dL (p=0.003). Conclusions: Comprehensive lifestyle modification lowers LDL-C with greater benefit among persons who attend more counseling sessions. Practice Implications: Patient engagement is a critical aspect of effective lifestyle interventions.
AB - Objective: To assess the effects of comprehensive lifestyle modification on low-density lipoprotein cholesterol (LDL-C) levels and whether greater participation in counseling sessions was associated with greater LDL-C reductions. Methods: Multicenter trial of Pre- or Stage 1 hypertensive adults randomized to: (1)Advice alone, (2)‘Established’ lifestyle intervention implementing physical activity, sodium reduction, and weight loss, if overweight, or (3)‘Established + DASH’ lifestyle intervention with DASH diet counseling. Both intervention groups received behavioral counseling. We used generalized estimating equations to model the intervention's effects on lipid outcomes. Analyses of number of sessions and lipids were adjusted for demographics and medical history. Results: Among 756 participants (mean age 49.7, 63.2% women, 34.7% black), both lifestyle interventions reduced LDL-C, triglycerides, and total cholesterol (TC) at six months. Compared to the ‘Advice’ arm, net mean lipid changes in the Established group were: LDL-C of -5.6 mg/dL (p=0.001) and TC of -7.3 mg/dL (p<0.001). Similarly, changes in the ‘Established + DASH’ group were: LDL-C of -4.0 mg/dL (p=0.03) and TC of -5.7 mg/dL (p=0.006). In dose-response analyses, for every 10-session increase, LDL-C changed by -6.2 mg/dL (p=0.003). Conclusions: Comprehensive lifestyle modification lowers LDL-C with greater benefit among persons who attend more counseling sessions. Practice Implications: Patient engagement is a critical aspect of effective lifestyle interventions.
KW - Cardiovascular disease
KW - Diet
KW - Epidemiology
KW - Lipids
KW - Patient engagement
KW - Randomized trial
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U2 - 10.1016/j.pec.2019.05.005
DO - 10.1016/j.pec.2019.05.005
M3 - Article
C2 - 31153659
AN - SCOPUS:85066294370
SN - 0738-3991
VL - 102
SP - 1882
EP - 1891
JO - Patient Education and Counseling
JF - Patient Education and Counseling
IS - 10
ER -