Dose dependence of Hymenoptera venom immunotherapy

David B.K. Golden; Anne Kagey-Sobotka; Martin D. Valentine; Lawrence M. Lichtenstein

doi:10.1016/0091-6749(81)90082-8

Dose dependence of Hymenoptera venom immunotherapy

David B.K. Golden, Anne Kagey-Sobotka, Martin D. Valentine, Lawrence M. Lichtenstein

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Abstract

The clinical and immunologic efficacy of venom immunotherapy up to 50 μg maintenance doses (half the recommended dose) was examined in 23 patients with anaphylactic sensitivity to insect stings and is compared with that in two groups of patients treated with the full 100-μg recommended dose. Four of the 19 patients challenged with insect stings had mild systemic reactions not requiring treatment. This 79% clinical efficacy is significantly less than the 96% to 100% success achieved with treatment to full 100-μg maintenance doses. The venom-specific IgG antibody response to the 50-μg dose reached a level significantly lower than that observed with 100-μg doses. We conclude that the clinical and immunologic responses to venom immunotherapy are dose dependent and are more reliably complete at the recommended maintenance dose of 100 μg of each venom than at a dose of 50 μg.

Original language	English (US)
Pages (from-to)	370-374
Number of pages	5
Journal	The Journal of allergy and clinical immunology
Volume	67
Issue number	5
DOIs	https://doi.org/10.1016/0091-6749(81)90082-8
State	Published - May 1981

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Dose dependence of Hymenoptera venom immunotherapy",

abstract = "The clinical and immunologic efficacy of venom immunotherapy up to 50 μg maintenance doses (half the recommended dose) was examined in 23 patients with anaphylactic sensitivity to insect stings and is compared with that in two groups of patients treated with the full 100-μg recommended dose. Four of the 19 patients challenged with insect stings had mild systemic reactions not requiring treatment. This 79% clinical efficacy is significantly less than the 96% to 100% success achieved with treatment to full 100-μg maintenance doses. The venom-specific IgG antibody response to the 50-μg dose reached a level significantly lower than that observed with 100-μg doses. We conclude that the clinical and immunologic responses to venom immunotherapy are dose dependent and are more reliably complete at the recommended maintenance dose of 100 μg of each venom than at a dose of 50 μg.",

author = "Golden, {David B.K.} and Anne Kagey-Sobotka and Valentine, {Martin D.} and Lichtenstein, {Lawrence M.}",

note = "Funding Information: From the Johns Hopkins University School of Medicine, Depart-ment of Medicine, Division of Clinical Immunology, The Good Samaritan Hospital. Supportedb y Grant AI 08270 from the National Institute of Allergy and Infectious Diseases. Received for publication Nov. 13, 1980. Accepted for publication Jan. 21, 1981. Reprint requests to: David B. K. Golden, M.D., The Johns Hop-kins University School of Mediiine at The Good Samaritan Hospital, 5601 L.och Raven Blvd., Baltimore, MD 21239. *F{\textquoteright}ublication No. 423 from the O{\textquoteright}Neill ResearchL aboratories, The Good Samaritan Hospital. **Supported by a Fellowship Grant from the Medical Research Council of Canada.",

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AU - Valentine, Martin D.

AU - Lichtenstein, Lawrence M.

N1 - Funding Information: From the Johns Hopkins University School of Medicine, Depart-ment of Medicine, Division of Clinical Immunology, The Good Samaritan Hospital. Supportedb y Grant AI 08270 from the National Institute of Allergy and Infectious Diseases. Received for publication Nov. 13, 1980. Accepted for publication Jan. 21, 1981. Reprint requests to: David B. K. Golden, M.D., The Johns Hop-kins University School of Mediiine at The Good Samaritan Hospital, 5601 L.och Raven Blvd., Baltimore, MD 21239. *F’ublication No. 423 from the O’Neill ResearchL aboratories, The Good Samaritan Hospital. **Supported by a Fellowship Grant from the Medical Research Council of Canada.

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N2 - The clinical and immunologic efficacy of venom immunotherapy up to 50 μg maintenance doses (half the recommended dose) was examined in 23 patients with anaphylactic sensitivity to insect stings and is compared with that in two groups of patients treated with the full 100-μg recommended dose. Four of the 19 patients challenged with insect stings had mild systemic reactions not requiring treatment. This 79% clinical efficacy is significantly less than the 96% to 100% success achieved with treatment to full 100-μg maintenance doses. The venom-specific IgG antibody response to the 50-μg dose reached a level significantly lower than that observed with 100-μg doses. We conclude that the clinical and immunologic responses to venom immunotherapy are dose dependent and are more reliably complete at the recommended maintenance dose of 100 μg of each venom than at a dose of 50 μg.

AB - The clinical and immunologic efficacy of venom immunotherapy up to 50 μg maintenance doses (half the recommended dose) was examined in 23 patients with anaphylactic sensitivity to insect stings and is compared with that in two groups of patients treated with the full 100-μg recommended dose. Four of the 19 patients challenged with insect stings had mild systemic reactions not requiring treatment. This 79% clinical efficacy is significantly less than the 96% to 100% success achieved with treatment to full 100-μg maintenance doses. The venom-specific IgG antibody response to the 50-μg dose reached a level significantly lower than that observed with 100-μg doses. We conclude that the clinical and immunologic responses to venom immunotherapy are dose dependent and are more reliably complete at the recommended maintenance dose of 100 μg of each venom than at a dose of 50 μg.

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Dose dependence of Hymenoptera venom immunotherapy

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