Dose dependence of Hymenoptera venom immunotherapy

David B.K. Golden, Anne Kagey-Sobotka, Martin D. Valentine, Lawrence M. Lichtenstein

Research output: Contribution to journalArticle


The clinical and immunologic efficacy of venom immunotherapy up to 50 μg maintenance doses (half the recommended dose) was examined in 23 patients with anaphylactic sensitivity to insect stings and is compared with that in two groups of patients treated with the full 100-μg recommended dose. Four of the 19 patients challenged with insect stings had mild systemic reactions not requiring treatment. This 79% clinical efficacy is significantly less than the 96% to 100% success achieved with treatment to full 100-μg maintenance doses. The venom-specific IgG antibody response to the 50-μg dose reached a level significantly lower than that observed with 100-μg doses. We conclude that the clinical and immunologic responses to venom immunotherapy are dose dependent and are more reliably complete at the recommended maintenance dose of 100 μg of each venom than at a dose of 50 μg.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalThe Journal of allergy and clinical immunology
Issue number5
StatePublished - May 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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