TY - JOUR
T1 - Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis
AU - Bi, Sheng
N1 - Funding Information:
This article is based on a presentation made during the 2012 Annual Meeting of the Society for the Study of Ingestive Behavior, July 10–14, 2012. The SSIB meeting was made possible in part by generous unrestricted donations from Novo Nordisk A/S, Research Diets, Inc., Sanofi, Inc., and TSE, Inc. This work was supported by the US National Institute of Diabetes and Digestive and Kidney Diseases grants DK074269 and DK087888 .
PY - 2013/9/10
Y1 - 2013/9/10
N2 - In addition to controlling food intake, the dorsomedial hypothalamus (DMH) plays an important role in thermoregulation. Within the DMH, a number of neuropeptides and receptors have been found and their roles in controlling energy balance are being investigated. We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH. Knockdown of NPY in the DMH promotes the development of brown adipocytes in white adipose tissue and increases brown adipocyte activity. DMH NPY knockdown also causes increased thermogenesis and energy expenditure. Finally, DMH NPY knockdown prevents high-fat diet-induced obesity and improves glucose homeostasis. This review focuses on the role of DMH NPY in modulating body adiposity and thermogenesis.
AB - In addition to controlling food intake, the dorsomedial hypothalamus (DMH) plays an important role in thermoregulation. Within the DMH, a number of neuropeptides and receptors have been found and their roles in controlling energy balance are being investigated. We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH. Knockdown of NPY in the DMH promotes the development of brown adipocytes in white adipose tissue and increases brown adipocyte activity. DMH NPY knockdown also causes increased thermogenesis and energy expenditure. Finally, DMH NPY knockdown prevents high-fat diet-induced obesity and improves glucose homeostasis. This review focuses on the role of DMH NPY in modulating body adiposity and thermogenesis.
KW - Brown adipocyte development
KW - Brown adipose tissue
KW - Dorsomedial hypothalamus
KW - Energy expenditure
KW - Neuropeptide Y
KW - Thermogenesis
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U2 - 10.1016/j.physbeh.2013.03.022
DO - 10.1016/j.physbeh.2013.03.022
M3 - Review article
C2 - 23562863
AN - SCOPUS:84887200977
SN - 0031-9384
VL - 121
SP - 56
EP - 60
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -