Dorsal horn neuron response patterns to graded heat stimuli in the rat

Jasenka Borzan, Stacey C. LaGraize, Doyle L. Hawkins, Yuan B. Peng

Research output: Contribution to journalArticle

Abstract

Sensory input from various receptors in the periphery first becomes integrated in the spinal cord dorsal horn. The response of the spinal cord dorsal horn neurons to mechanical stimuli are classified as low threshold, high threshold, and wide dynamic range neurons. However, the response pattern of deep dorsal horn cells to heat has not been well described. In this study, the response of the spinal cord dorsal horn neurons to graded heat stimuli were characterized in 147 neurons in rats by extracellular single cell recording. After a differentiable cell was identified, the Peltier heat stimulator was applied to the receptive field and the base temperature was set at 30°C. The heat stimulus was delivered for 10 s from 37-51°C in 2°C increments, with an inter-stimulus interval of 30 s. Out of the 147 neurons, five statistically distinguishable response patterns were identified by latent class cluster analysis. It is concluded that variation of temperature may account for the observed results and indicate functionally different subsets of heat-responsive cells in the deep dorsal horn.

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalBrain Research
Volume1045
Issue number1-2
DOIs
StatePublished - May 31 2005
Externally publishedYes

Fingerprint

Posterior Horn Cells
Hot Temperature
Neurons
Temperature
Cluster Analysis
Spinal Cord Dorsal Horn

Keywords

  • Dorsal horn neuron
  • Primary afferent
  • Spinal cord
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Borzan, J., LaGraize, S. C., Hawkins, D. L., & Peng, Y. B. (2005). Dorsal horn neuron response patterns to graded heat stimuli in the rat. Brain Research, 1045(1-2), 72-79. https://doi.org/10.1016/j.brainres.2005.03.030

Dorsal horn neuron response patterns to graded heat stimuli in the rat. / Borzan, Jasenka; LaGraize, Stacey C.; Hawkins, Doyle L.; Peng, Yuan B.

In: Brain Research, Vol. 1045, No. 1-2, 31.05.2005, p. 72-79.

Research output: Contribution to journalArticle

Borzan, J, LaGraize, SC, Hawkins, DL & Peng, YB 2005, 'Dorsal horn neuron response patterns to graded heat stimuli in the rat', Brain Research, vol. 1045, no. 1-2, pp. 72-79. https://doi.org/10.1016/j.brainres.2005.03.030
Borzan, Jasenka ; LaGraize, Stacey C. ; Hawkins, Doyle L. ; Peng, Yuan B. / Dorsal horn neuron response patterns to graded heat stimuli in the rat. In: Brain Research. 2005 ; Vol. 1045, No. 1-2. pp. 72-79.
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