Dorsal hippocampal lesion does not affect dopaminergic indices in the basal ganglia

Barbara K. Lipska; George E. Jaskiw; Farouk Karoum; Ingrid Phillips; Joel E. Kleinman; Daniel R. Weinberger

doi:10.1016/0091-3057(91)90342-Y

Dorsal hippocampal lesion does not affect dopaminergic indices in the basal ganglia

Barbara K. Lipska, George E. Jaskiw, Farouk Karoum, Ingrid Phillips, Joel E. Kleinman, Daniel R. Weinberger

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

To determine the influence of intrinsic neurons of the dorsal hippocampus on dopamine (DA) turnover in other limbic areas, DA and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the dorsal hippocampus in the rat. The locomotor response to d-amphetamine was also assessed. Spontaneous locomotion was increased 14 but not 28 days postoperatively. There was no change in d-ampetamine-induced locomotion at any time. Presynaptic indices of DA turnover in the medial prefrontal cortex, anteromedial striatum and nucleus accumbens were not affected by the lesion. Unlike lesions of the medial prefrontal cortex, deefferentation of the dorsal hippocampus does not increase DA turnover in the basal ganglia.

Original language	English (US)
Pages (from-to)	181-184
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(91)90342-Y
State	Published - Sep 1991
Externally published	Yes

Keywords

Amphetamine
Dopamine
Dorsal hippocampus
Ibotenic acid
Locomotor response
Nucleus accumbes

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(91)90342-Y

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title = "Dorsal hippocampal lesion does not affect dopaminergic indices in the basal ganglia",

abstract = "To determine the influence of intrinsic neurons of the dorsal hippocampus on dopamine (DA) turnover in other limbic areas, DA and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the dorsal hippocampus in the rat. The locomotor response to d-amphetamine was also assessed. Spontaneous locomotion was increased 14 but not 28 days postoperatively. There was no change in d-ampetamine-induced locomotion at any time. Presynaptic indices of DA turnover in the medial prefrontal cortex, anteromedial striatum and nucleus accumbens were not affected by the lesion. Unlike lesions of the medial prefrontal cortex, deefferentation of the dorsal hippocampus does not increase DA turnover in the basal ganglia.",

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T1 - Dorsal hippocampal lesion does not affect dopaminergic indices in the basal ganglia

AU - Lipska, Barbara K.

AU - Jaskiw, George E.

AU - Karoum, Farouk

AU - Phillips, Ingrid

AU - Kleinman, Joel E.

AU - Weinberger, Daniel R.

PY - 1991/9

Y1 - 1991/9

N2 - To determine the influence of intrinsic neurons of the dorsal hippocampus on dopamine (DA) turnover in other limbic areas, DA and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the dorsal hippocampus in the rat. The locomotor response to d-amphetamine was also assessed. Spontaneous locomotion was increased 14 but not 28 days postoperatively. There was no change in d-ampetamine-induced locomotion at any time. Presynaptic indices of DA turnover in the medial prefrontal cortex, anteromedial striatum and nucleus accumbens were not affected by the lesion. Unlike lesions of the medial prefrontal cortex, deefferentation of the dorsal hippocampus does not increase DA turnover in the basal ganglia.

AB - To determine the influence of intrinsic neurons of the dorsal hippocampus on dopamine (DA) turnover in other limbic areas, DA and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the dorsal hippocampus in the rat. The locomotor response to d-amphetamine was also assessed. Spontaneous locomotion was increased 14 but not 28 days postoperatively. There was no change in d-ampetamine-induced locomotion at any time. Presynaptic indices of DA turnover in the medial prefrontal cortex, anteromedial striatum and nucleus accumbens were not affected by the lesion. Unlike lesions of the medial prefrontal cortex, deefferentation of the dorsal hippocampus does not increase DA turnover in the basal ganglia.

KW - Amphetamine

KW - Dopamine

KW - Dorsal hippocampus

KW - Ibotenic acid

KW - Locomotor response

KW - Nucleus accumbes

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Dorsal hippocampal lesion does not affect dopaminergic indices in the basal ganglia

Abstract

Keywords

ASJC Scopus subject areas

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