Dorsal hippocampal lesion abolishes the response to FG-7142 in the rat

Barabara K. Lipska, George E. Jaskiw, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the anxiogenic β-carboline FG-7142 (15 mg/kg IP) on exploratory locomotor activity were assessed in rats with sham or ibotenic acid (IA) lesions of the dorsal or ventral hippocampus. FG-7142 reduced exploratory activity similarly in control animals as well as in those with IA lesions of the ventral hippocampus. In contrast, FG-7142 had no effect on rats with dorsal hippocampal lesions. The results suggest that the dorsal hippocampus plays a unique role in FG-7142-mediated attenuation of locomotor exploration. Other studies suggest that serotonergic systems may mediate these properties of FG-7142.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume40
Issue number1
DOIs
StatePublished - Sep 1991
Externally publishedYes

Keywords

  • Dorsal hippocampus
  • Exploration
  • FG-7142
  • Ibotenic acid lesion
  • Locomotion
  • Ventral hippocampus

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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