Abstract
The effects of the anxiogenic β-carboline FG-7142 (15 mg/kg IP) on exploratory locomotor activity were assessed in rats with sham or ibotenic acid (IA) lesions of the dorsal or ventral hippocampus. FG-7142 reduced exploratory activity similarly in control animals as well as in those with IA lesions of the ventral hippocampus. In contrast, FG-7142 had no effect on rats with dorsal hippocampal lesions. The results suggest that the dorsal hippocampus plays a unique role in FG-7142-mediated attenuation of locomotor exploration. Other studies suggest that serotonergic systems may mediate these properties of FG-7142.
Original language | English (US) |
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Pages (from-to) | 169-172 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 40 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1991 |
Externally published | Yes |
Keywords
- Dorsal hippocampus
- Exploration
- FG-7142
- Ibotenic acid lesion
- Locomotion
- Ventral hippocampus
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience