Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome

M. Clara Sañudo-Peña; Michelle Force; Tsou Kang; Gabrielle McLemore; Langdon Roberts; J. Michael Walker

Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome

M. Clara Sañudo-Peña, Michelle Force, Tsou Kang, Gabrielle McLemore, Langdon Roberts, J. Michael Walker

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome. METHODS: The dopamine D₁ receptor antagonist SCH23390 or the dopamine D₂ receptor antagonist sulpiride was administered to rats chronically treated with either Δ⁹- tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle and behavior was observed for 1 h. RESULTS: Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome. CONCLUSION: It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome.

Original language	English (US)
Pages (from-to)	1121-1124
Number of pages	4
Journal	Acta Pharmacologica Sinica
Volume	20
Issue number	12
State	Published - 1999
Externally published	Yes

Keywords

Cannabinoids
Dopamine antagonists
Dopamine D receptors
Dopamine D receptors
Pain
Pruritus
SR141716A
Substance withdrawal syndrome
Tetrahydrocannabinol

ASJC Scopus subject areas

Chemistry(all)
Pharmacology

Cite this

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title = "Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome",

abstract = "AIM: To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome. METHODS: The dopamine D1 receptor antagonist SCH23390 or the dopamine D2 receptor antagonist sulpiride was administered to rats chronically treated with either Δ9- tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle and behavior was observed for 1 h. RESULTS: Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome. CONCLUSION: It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome.",

keywords = "Cannabinoids, Dopamine antagonists, Dopamine D receptors, Dopamine D receptors, Pain, Pruritus, SR141716A, Substance withdrawal syndrome, Tetrahydrocannabinol",

author = "Sa{\~n}udo-Pe{\~n}a, {M. Clara} and Michelle Force and Tsou Kang and Gabrielle McLemore and Langdon Roberts and Walker, {J. Michael}",

year = "1999",

language = "English (US)",

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journal = "Acta Pharmacologica Sinica",

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}

TY - JOUR

T1 - Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome

AU - Sañudo-Peña, M. Clara

AU - Force, Michelle

AU - Kang, Tsou

AU - McLemore, Gabrielle

AU - Roberts, Langdon

AU - Walker, J. Michael

PY - 1999

Y1 - 1999

N2 - AIM: To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome. METHODS: The dopamine D1 receptor antagonist SCH23390 or the dopamine D2 receptor antagonist sulpiride was administered to rats chronically treated with either Δ9- tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle and behavior was observed for 1 h. RESULTS: Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome. CONCLUSION: It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome.

AB - AIM: To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome. METHODS: The dopamine D1 receptor antagonist SCH23390 or the dopamine D2 receptor antagonist sulpiride was administered to rats chronically treated with either Δ9- tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle and behavior was observed for 1 h. RESULTS: Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome. CONCLUSION: It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome.

KW - Cannabinoids

KW - Dopamine antagonists

KW - Dopamine D receptors

KW - Pain

KW - Pruritus

KW - SR141716A

KW - Substance withdrawal syndrome

KW - Tetrahydrocannabinol

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C2 - 11216447

AN - SCOPUS:0032761241

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JO - Acta Pharmacologica Sinica

JF - Acta Pharmacologica Sinica

SN - 1671-4083

IS - 12

ER -

Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome

Abstract

Keywords

ASJC Scopus subject areas

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