Dopaminergic dysfunction in tourette syndrome

Harvey S. Singer; Ian J. Butler; Larry E. Tune; William E. Seifert; Joseph T. Coyle

doi:10.1002/ana.410120408

Dopaminergic dysfunction in tourette syndrome

Harvey S. Singer, Ian J. Butler, Larry E. Tune, William E. Seifert, Joseph T. Coyle

Johns Hopkins Hospital

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome. Pretteatment cerebrospinal fluid levels of homovanillic acid (CSF HV A) were significantly reduced in all patients, whereas 5‐hydroxyindoleacetic acid was reduced in only two. With haloperidol treatment, symptoms decreased in all cases (21 to 88%) and clinical improvement was associated withan increased level of CSF HV A, often returning to the normal range. Optimal therapeutic response was found with serum levels of haloperidol between 1 and 4 ng/ml; however, disturbing side effects also occurred within this range. These results support the hypothesis that Tourette syndrome may result form a supersensitivity of dopaminergic receptors.

Original language	English (US)
Pages (from-to)	361-366
Number of pages	6
Journal	Annals of neurology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1002/ana.410120408
State	Published - Oct 1982

ASJC Scopus subject areas

Neurology
Clinical Neurology

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AU - Seifert, William E.

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Dopaminergic dysfunction in tourette syndrome

Abstract

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