Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats

Hadi Fathi Moghaddam; Mehdi Shafiee Ardestani; Mostafa Saffari; Latifeh Navidpour; Abbas Shafiee; Arman Rahmim

doi:10.1111/j.1742-7843.2008.00295.x

Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats

Hadi Fathi Moghaddam, Mehdi Shafiee Ardestani, Mostafa Saffari, Latifeh Navidpour, Abbas Shafiee, Arman Rahmim

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In the present work, we studied the effect of the selective cyclooxygenase-2 (COX-2) inhibitors, compound 11 g, celecoxib and selective COX-1 inhibitor SC-560 (intraperitoneally and acutely) on striatal glutamatergic and dopaminergic neurotransmission in normal and substantia nigra pars compacta (SNc)-lesioned rats using the microdialysis technique. We also investigated the effect of acute COX inhibition on the damaged SNc neurons. Our results indicate a significant increase in dopaminergic neurotransmission and a decrease in glutamatergic neurotransmission (P < 0.05) only after selective COX-2 inhibition in the striatum of normal and hemiparkinsonian rats. Nonetheless, neither COX-1 nor COX-2 inhibitors showed any improvement in the damaged SNc neurons.

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	103
Issue number	4
DOIs	https://doi.org/10.1111/j.1742-7843.2008.00295.x
State	Published - Oct 2008
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1111/j.1742-7843.2008.00295.x

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Fathi Moghaddam, H., Ardestani, M. S., Saffari, M., Navidpour, L., Shafiee, A., & Rahmim, A. (2008). Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats. Basic and Clinical Pharmacology and Toxicology, 103(4), 293-296. https://doi.org/10.1111/j.1742-7843.2008.00295.x

Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats. / Fathi Moghaddam, Hadi; Ardestani, Mehdi Shafiee; Saffari, Mostafa et al.
In: Basic and Clinical Pharmacology and Toxicology, Vol. 103, No. 4, 10.2008, p. 293-296.

Research output: Contribution to journal › Article › peer-review

Fathi Moghaddam, H, Ardestani, MS, Saffari, M, Navidpour, L, Shafiee, A & Rahmim, A 2008, 'Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats', Basic and Clinical Pharmacology and Toxicology, vol. 103, no. 4, pp. 293-296. https://doi.org/10.1111/j.1742-7843.2008.00295.x

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abstract = "In the present work, we studied the effect of the selective cyclooxygenase-2 (COX-2) inhibitors, compound 11 g, celecoxib and selective COX-1 inhibitor SC-560 (intraperitoneally and acutely) on striatal glutamatergic and dopaminergic neurotransmission in normal and substantia nigra pars compacta (SNc)-lesioned rats using the microdialysis technique. We also investigated the effect of acute COX inhibition on the damaged SNc neurons. Our results indicate a significant increase in dopaminergic neurotransmission and a decrease in glutamatergic neurotransmission (P < 0.05) only after selective COX-2 inhibition in the striatum of normal and hemiparkinsonian rats. Nonetheless, neither COX-1 nor COX-2 inhibitors showed any improvement in the damaged SNc neurons.",

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AU - Navidpour, Latifeh

AU - Shafiee, Abbas

AU - Rahmim, Arman

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Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats

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