Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats

Hadi Fathi Moghaddam, Mehdi Shafiee Ardestani, Mostafa Saffari, Latifeh Navidpour, Abbas Shafiee, Arman Rahmim

Research output: Contribution to journalArticlepeer-review

Abstract

In the present work, we studied the effect of the selective cyclooxygenase-2 (COX-2) inhibitors, compound 11 g, celecoxib and selective COX-1 inhibitor SC-560 (intraperitoneally and acutely) on striatal glutamatergic and dopaminergic neurotransmission in normal and substantia nigra pars compacta (SNc)-lesioned rats using the microdialysis technique. We also investigated the effect of acute COX inhibition on the damaged SNc neurons. Our results indicate a significant increase in dopaminergic neurotransmission and a decrease in glutamatergic neurotransmission (P < 0.05) only after selective COX-2 inhibition in the striatum of normal and hemiparkinsonian rats. Nonetheless, neither COX-1 nor COX-2 inhibitors showed any improvement in the damaged SNc neurons.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalBasic and Clinical Pharmacology and Toxicology
Volume103
Issue number4
DOIs
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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