Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum

George Ricaurte, J. W. Langston, L. E. DeLanney, I. Irwin, J. D. Brooks

Research output: Contribution to journalArticle

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a recently described neurotoxin, produces a marked dopamine (DA) depletion in the mouse striatum. In this study, a series of DA uptake blockers was tested for their ability to prevent this effect of MPTP. The agents tested (amfonelic acid, benztropine, bupropion and mazindol) completely protected against DA depletion in the mouse striatum when given before DA-depleting doses of MPTP were administered, whereas atropine and trihexyphenidyl (which were employed for comparative purposes) did not. DA uptake blocking agents appear to represent a second general class of compounds, monoamine oxidase inhibitors being the first, which protect against the biologic effects of MPTP in the mouse.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalNeuroscience Letters
Volume59
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopamine Agents
Dopamine Antagonists
Dopamine
Benztropine
Trihexyphenidyl
Mazindol
Bupropion
Monoamine Oxidase Inhibitors
Neurotoxins
Atropine

ASJC Scopus subject areas

  • Neuroscience(all)

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Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum. / Ricaurte, George; Langston, J. W.; DeLanney, L. E.; Irwin, I.; Brooks, J. D.

In: Neuroscience Letters, Vol. 59, No. 3, 1985, p. 259-264.

Research output: Contribution to journalArticle

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