Dopamine transporter SPECT imaging in parkinson disease and dementia

Devaki Shilpa Surasi, Patrick J. Peller, Zsolt Szabo, Gustavo Mercier, Rathan Subramaniam

Research output: Contribution to journalReview articlepeer-review


The diagnosis of Parkinson disease (PD) and dementia with Lewy bodies (DLB) is often not straightforward. When PD symptoms are atypical or overlap with other diseases (eg, essential tremor [ET] or drug induced), [123I] N-ω-fluoropropyl-2β-carbomethoxy-3b-(4-iodophenyl) nortropane ([ 123I]FP-CIT) single-photon emission computed tomography (SPECT) can improve the diagnostic accuracy. The potential side effects of medications for PD may be avoided, if [123I]FP-CIT SPECT is normal. [ 123I]FP-CIT SPECT is helpful in the diagnosis of DLB, differentiating it from other causes of dementia such as Alzheimer disease (AD).

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalPET Clinics
Issue number4
StatePublished - Oct 2013


  • Dementia
  • Dopamine
  • Parkinson disease

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging


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