Dopamine transporter mRNA: dense expression in ventral midbrain neurons

Shoichi Shimada, Shigeo Kitayama, Donna Walther, George Uhl

Research output: Contribution to journalArticle

Abstract

Oligonucleotides and a full-length cDNA encoding a functional dopamine transporter (DAT1) hybridize to a 3.7 kb mRNA that is concentrated in mRNA prepared from midbrain and absent in specimens from cerebellum or cerebral cortex. In situ hybridization reveals substantial hybridization densities overlying neurons of the substantia nigra, pars compacta, and the parabrachialis pigmentosus region of the ventral tegmental area (VTA). Neurons in the linear and paranigral VTA regions display lower levels of expression. Preliminary studies in arcuate neurons suggest modest hybridization. Different dopaminergic cell groups display different levels of DAT1 dopamine transporter expression.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalMolecular Brain Research
Volume13
Issue number4
DOIs
StatePublished - 1992

Keywords

  • Dopamine transporter mRNA
  • Substantia nigra
  • Ventral tegmental area

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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