Dopamine transporter dysfunction in Han Chinese people with chronic methamphetamine dependence after a short-term abstinence

Jie Yuan, Rongbin Lv, James Robert Brašić, Mei Han, Xingdang Liu, Yuankai Wang, Guangming Zhang, Congjin Liu, Yu Li, Yanping Deng

Research output: Contribution to journalArticlepeer-review

Abstract

Single-photon emission-computed tomography (SPECT) after the administration of 99mTc-TRODAT-1 was performed on healthy subjects and subjects with methamphetamine (METH)dependence at time 1 (T1) after 24-48h of abstinence, time 2 (T2) after 2 weeks of abstinence, and time 3 (T3) after 4 weeks of abstinence. In contrast to values in controls, the values of the striatal DAT specific uptake ratios (SURs) in subjects with METH dependence were significantly lower at T1 (n=25), T2 (n=9), and T3 (n=8); a mild increase in SURs was observed at T2 and T3, but values were still significantly lower than those in controls. In subjects with METH dependence, there was a trend for a negative correlation of striatal DAT SURs and craving for METH at T1. METH craving, anxiety and depression scores significantly decreased from T1 to T2 to T3. We conclude that Han Chinese people with METH dependence experience significant striatal DAT dysfunction, and that these changes may be mildly reversible after 4 weeks of abstinence, but that DAT levels still remain significantly lower than those in healthy subjects. The mild recovery of striatal DAT may parallel improvements in craving, anxiety and depression.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume221
Issue number1
DOIs
StatePublished - Jan 30 2014

Keywords

  • Dopamine transporter (DAT) tomography
  • Emission-computed
  • Methamphetamine (METH) abuse
  • Single-photon
  • Tc-TRODAT-1

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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