Dopamine receptors, neuroleptics, and schizophrenia

Research output: Contribution to journalArticle

Abstract

The antipsychotic effects of neuroleptic drugs are mediated by dopamine DA-2 receptors, and dopamine DA-1 receptors, linked to cyclic AMP formation, are not involved. Dopamine receptor binding is enhanced in brain specimens of deceased schizophrenic patients, an increase which may relate to chronic neuroleptic treatment. The binding of 3H-butyrophenones to dopamine receptors can be used for a radioreceptor assay that detects blood levels of all clinically used neuroleptics and their pharmacologically active metabolites and may facilitate routine monitoring of blood levels.

Original languageEnglish (US)
Pages (from-to)460-464
Number of pages5
JournalAmerican Journal of Psychiatry
Volume138
Issue number4
StatePublished - 1981

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Dopamine Receptors
Antipsychotic Agents
Schizophrenia
Butyrophenones
Radioligand Assay
Cyclic AMP
Dopamine
Brain
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Dopamine receptors, neuroleptics, and schizophrenia. / Snyder, Solomon H.

In: American Journal of Psychiatry, Vol. 138, No. 4, 1981, p. 460-464.

Research output: Contribution to journalArticle

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