Abstract
3H-Spiroperidol labels dopamine receptors in rats striatum but in frontal cortex and hippocampus 3H-spiroperidol labels serotonin receptors. The agonists 3H-ADTN and 3H-apomorphine label rat striatal dopamine receptors. Comparison with calf striatal binding indicates a species difference in 3H-apomorphine binding. Drug displacement and lesion studies suggest that in the rat 3H-apomorphine labels two distinct dopamine receptors, one associated with the dopamine-sensitive adenylate cyclase and the other with presynaptic dopamine receptors also labeled by 3H-spiroperidol. Whereas divalent cations increase specific dopamine receptor binding of 3H-agonists and 3H-antagonists, 3H-agonist binding is selectively decreased by some guanyl nucleotides.
Original language | English (US) |
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Pages (from-to) | 495-499 |
Number of pages | 5 |
Journal | Life Sciences |
Volume | 23 |
Issue number | 5 |
DOIs | |
State | Published - Aug 7 1978 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)