Abstract
3H-Spiroperidol labels dopamine receptors in rats striatum but in frontal cortex and hippocampus 3H-spiroperidol labels serotonin receptors. The agonists 3H-ADTN and 3H-apomorphine label rat striatal dopamine receptors. Comparison with calf striatal binding indicates a species difference in 3H-apomorphine binding. Drug displacement and lesion studies suggest that in the rat 3H-apomorphine labels two distinct dopamine receptors, one associated with the dopamine-sensitive adenylate cyclase and the other with presynaptic dopamine receptors also labeled by 3H-spiroperidol. Whereas divalent cations increase specific dopamine receptor binding of 3H-agonists and 3H-antagonists, 3H-agonist binding is selectively decreased by some guanyl nucleotides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 495-499 |
| Number of pages | 5 |
| Journal | Life Sciences |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - Aug 7 1978 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Dopamine receptor binding : Specificity, localization and regulation by ions and guanyl nucleotides. / Creese, Ian; Prosser, Timothy; Snyder, Solomon H.
In: Life Sciences, Vol. 23, No. 5, 07.08.1978, p. 495-499.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dopamine receptor binding
T2 - Specificity, localization and regulation by ions and guanyl nucleotides
AU - Creese, Ian
AU - Prosser, Timothy
AU - Snyder, Solomon H
PY - 1978/8/7
Y1 - 1978/8/7
N2 - 3H-Spiroperidol labels dopamine receptors in rats striatum but in frontal cortex and hippocampus 3H-spiroperidol labels serotonin receptors. The agonists 3H-ADTN and 3H-apomorphine label rat striatal dopamine receptors. Comparison with calf striatal binding indicates a species difference in 3H-apomorphine binding. Drug displacement and lesion studies suggest that in the rat 3H-apomorphine labels two distinct dopamine receptors, one associated with the dopamine-sensitive adenylate cyclase and the other with presynaptic dopamine receptors also labeled by 3H-spiroperidol. Whereas divalent cations increase specific dopamine receptor binding of 3H-agonists and 3H-antagonists, 3H-agonist binding is selectively decreased by some guanyl nucleotides.
AB - 3H-Spiroperidol labels dopamine receptors in rats striatum but in frontal cortex and hippocampus 3H-spiroperidol labels serotonin receptors. The agonists 3H-ADTN and 3H-apomorphine label rat striatal dopamine receptors. Comparison with calf striatal binding indicates a species difference in 3H-apomorphine binding. Drug displacement and lesion studies suggest that in the rat 3H-apomorphine labels two distinct dopamine receptors, one associated with the dopamine-sensitive adenylate cyclase and the other with presynaptic dopamine receptors also labeled by 3H-spiroperidol. Whereas divalent cations increase specific dopamine receptor binding of 3H-agonists and 3H-antagonists, 3H-agonist binding is selectively decreased by some guanyl nucleotides.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018094325&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(78)90160-1
DO - 10.1016/0024-3205(78)90160-1
M3 - Article
C2 - 692273
AN - SCOPUS:0018094325
VL - 23
SP - 495
EP - 499
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 5
ER -