Dopamine receptor binding: Specificity, localization and regulation by ions and guanyl nucleotides

Ian Creese; Timothy Prosser; Solomon H. Snyder

doi:10.1016/0024-3205(78)90160-1

Dopamine receptor binding: Specificity, localization and regulation by ions and guanyl nucleotides

Ian Creese, Timothy Prosser, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article

Abstract

³H-Spiroperidol labels dopamine receptors in rats striatum but in frontal cortex and hippocampus ³H-spiroperidol labels serotonin receptors. The agonists ³H-ADTN and ³H-apomorphine label rat striatal dopamine receptors. Comparison with calf striatal binding indicates a species difference in ³H-apomorphine binding. Drug displacement and lesion studies suggest that in the rat ³H-apomorphine labels two distinct dopamine receptors, one associated with the dopamine-sensitive adenylate cyclase and the other with presynaptic dopamine receptors also labeled by ³H-spiroperidol. Whereas divalent cations increase specific dopamine receptor binding of ³H-agonists and ³H-antagonists, ³H-agonist binding is selectively decreased by some guanyl nucleotides.

Original language	English (US)
Pages (from-to)	495-499
Number of pages	5
Journal	Life Sciences
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(78)90160-1
State	Published - Aug 7 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(78)90160-1

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Creese, I., Prosser, T., & Snyder, S. H. (1978). Dopamine receptor binding: Specificity, localization and regulation by ions and guanyl nucleotides. Life Sciences, 23(5), 495-499. https://doi.org/10.1016/0024-3205(78)90160-1

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abstract = "3H-Spiroperidol labels dopamine receptors in rats striatum but in frontal cortex and hippocampus 3H-spiroperidol labels serotonin receptors. The agonists 3H-ADTN and 3H-apomorphine label rat striatal dopamine receptors. Comparison with calf striatal binding indicates a species difference in 3H-apomorphine binding. Drug displacement and lesion studies suggest that in the rat 3H-apomorphine labels two distinct dopamine receptors, one associated with the dopamine-sensitive adenylate cyclase and the other with presynaptic dopamine receptors also labeled by 3H-spiroperidol. Whereas divalent cations increase specific dopamine receptor binding of 3H-agonists and 3H-antagonists, 3H-agonist binding is selectively decreased by some guanyl nucleotides.",

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