Dopamine receptor binding regulated by guanine nucleotides

I. Creese, T. B. Usdin, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalMolecular Pharmacology
Volume16
Issue number1
StatePublished - 1979

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Guanine Nucleotides
Dopamine Receptors
Spiperone
Apomorphine
Guanosine Triphosphate
Nucleotides
Guanosine Monophosphate
Corpus Striatum
Adenine Nucleotides
Diphosphates
Binding Sites
Ligands

ASJC Scopus subject areas

  • Pharmacology

Cite this

Dopamine receptor binding regulated by guanine nucleotides. / Creese, I.; Usdin, T. B.; Snyder, Solomon H.

In: Molecular Pharmacology, Vol. 16, No. 1, 1979, p. 69-76.

Research output: Contribution to journalArticle

Creese, I. ; Usdin, T. B. ; Snyder, Solomon H. / Dopamine receptor binding regulated by guanine nucleotides. In: Molecular Pharmacology. 1979 ; Vol. 16, No. 1. pp. 69-76.
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