Abstract
Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.
Original language | English (US) |
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Pages (from-to) | 69-76 |
Number of pages | 8 |
Journal | Molecular Pharmacology |
Volume | 16 |
Issue number | 1 |
State | Published - Dec 1 1979 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology