Abstract
Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-76 |
| Number of pages | 8 |
| Journal | Molecular Pharmacology |
| Volume | 16 |
| Issue number | 1 |
| State | Published - 1979 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
Cite this
Dopamine receptor binding regulated by guanine nucleotides. / Creese, I.; Usdin, T. B.; Snyder, Solomon H.
In: Molecular Pharmacology, Vol. 16, No. 1, 1979, p. 69-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dopamine receptor binding regulated by guanine nucleotides
AU - Creese, I.
AU - Usdin, T. B.
AU - Snyder, Solomon H
PY - 1979
Y1 - 1979
N2 - Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.
AB - Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.
UR - http://www.scopus.com/inward/record.url?scp=0018759454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018759454&partnerID=8YFLogxK
M3 - Article
C2 - 481426
AN - SCOPUS:0018759454
VL - 16
SP - 69
EP - 76
JO - Molecular Pharmacology
JF - Molecular Pharmacology
SN - 0026-895X
IS - 1
ER -