Dopamine receptor binding regulated by guanine nucleotides

I. Creese, T. B. Usdin, S. H. Snyder

Research output: Contribution to journalArticle

Abstract

Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalMolecular Pharmacology
Volume16
Issue number1
StatePublished - Dec 1 1979

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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