Abstract
Guanosine triphosphate (GTP) and diphosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 μM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-76 |
| Number of pages | 8 |
| Journal | Molecular Pharmacology |
| Volume | 16 |
| Issue number | 1 |
| State | Published - Dec 1 1979 |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
Cite this
Creese, I., Usdin, T. B., & Snyder, S. H. (1979). Dopamine receptor binding regulated by guanine nucleotides. Molecular Pharmacology, 16(1), 69-76.