Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

Ian Creese, David R. Burt, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

Original languageEnglish (US)
Pages (from-to)481-483
Number of pages3
JournalScience
Volume192
Issue number4238
StatePublished - 1976

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Dopamine Receptors
Haloperidol
Butyrophenones
Pharmacology
Phenothiazines
Pharmaceutical Preparations
Dopamine
Brain
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. / Creese, Ian; Burt, David R.; Snyder, Solomon H.

In: Science, Vol. 192, No. 4238, 1976, p. 481-483.

Research output: Contribution to journalArticle

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