Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

I. Creese, D. R. Burt, S. H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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