Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity

Ian Creese, David R. Burt, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalScience
Volume197
Issue number4303
DOIs
StatePublished - Jan 1 1977

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