Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity

Ian Creese, David R. Burt, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

583 Scopus citations

Abstract

The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalScience
Volume197
Issue number4303
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity'. Together they form a unique fingerprint.

Cite this