Abstract
The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.
Original language | English (US) |
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Pages (from-to) | 596-598 |
Number of pages | 3 |
Journal | Science |
Volume | 197 |
Issue number | 4303 |
DOIs | |
State | Published - 1977 |
ASJC Scopus subject areas
- General