Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity

Ian Creese, David R. Burt, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalScience
Volume197
Issue number4303
StatePublished - 1977

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Dopamine Receptors
Corpus Striatum
Apomorphine
Oxidopamine
Haloperidol
Dopamine
Injections

ASJC Scopus subject areas

  • General

Cite this

Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. / Creese, Ian; Burt, David R.; Snyder, Solomon H.

In: Science, Vol. 197, No. 4303, 1977, p. 596-598.

Research output: Contribution to journalArticle

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