Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata

Michael R. Weed, William L. Woolverton, Ian A. Paul

Research output: Contribution to journalArticle

Abstract

Several phenyl-benzazepine compounds, putatively selective dopamine D1 receptor agonists, have been used to study the effects of dopamine D1 receptor stimulation in rodents and nonhuman primates. However, the dopamine receptor selectivities of these compounds have not been established in nonhuman primates. Accordingly, the relative selectivities of six phenyl-benzazepines for dopamine D1-like and D2-like receptors were assessed in rhesus monkey and, for comparison, rat striata. The compounds tested had higher affinity for D1 than D2 receptors in both species; however, their selectivity varied by up to three orders of magnitude. GTP (100 μM) reduced agonist binding at the high-affinity state of the dopamine D1 receptor, but the magnitude of the effect of GTP did not reliably predict a compound's efficacy. Furthermore, a history of cocaine self-administration did not appear to influence dopamine receptor binding characteristics in the rhesus monkeys in this study. The present results will aid the comparison of dopamine receptor binding characteristics and behavioral effects of D1 dopamine receptor agonists. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)129-142
Number of pages14
JournalEuropean Journal of Pharmacology
Volume361
Issue number1
DOIs
StatePublished - Nov 13 1998
Externally publishedYes

Keywords

  • (Rat)
  • (Rhesus monkey)
  • Dopamine
  • Dopamine receptor agonist
  • Dopamine receptor antagonist
  • Phenyl-benzazepine
  • Radioligand binding
  • SCH 23390
  • Spiperone

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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