Dopamine D-2 auto- and postsynaptic receptors in the nigrostriatal system of the rat brain: localization by quantitative autoradiography with [3H]sulpiride

Francis M. Filloux, James K. Wamsley, Ted M. Dawson

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro receptor autoradiography with [3H]sulpiride (a selective D-2 antagonist) was used to assess the effect of 6-hydroxydopamine and ibotenic acid lesions of the caudate-putamen and substantia nigra pars compacta on D-2 dopamine receptors in rat brain. A marked reduction in [3H]sulpiride binding within the pars compacta of the substantia nigra resulted from lesions of the substantia nigra compacta with either toxin, while substantial reduction in binding within the caudate-putamen followed only ibotenate lesions of that structure. Since (-)sulpiride is a selective D-2 antagonist, these data confirm that autoreceptors on nigral DA neurons are of the D-2 type, while a portion of D-2 receptors in the caudate-putamen are postsynaptic on striatal neurons.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalEuropean Journal of Pharmacology
Volume138
Issue number1
DOIs
StatePublished - Jun 12 1987
Externally publishedYes

Keywords

  • 6-Hydroxydopamine
  • Autoradiography
  • Autoreceptors
  • D-2 dopamine receptors
  • Ibotenic acid
  • Substantia nigra
  • Sulpiride

ASJC Scopus subject areas

  • Pharmacology

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