Abstract
In vitro receptor autoradiography with [3H]sulpiride (a selective D-2 antagonist) was used to assess the effect of 6-hydroxydopamine and ibotenic acid lesions of the caudate-putamen and substantia nigra pars compacta on D-2 dopamine receptors in rat brain. A marked reduction in [3H]sulpiride binding within the pars compacta of the substantia nigra resulted from lesions of the substantia nigra compacta with either toxin, while substantial reduction in binding within the caudate-putamen followed only ibotenate lesions of that structure. Since (-)sulpiride is a selective D-2 antagonist, these data confirm that autoreceptors on nigral DA neurons are of the D-2 type, while a portion of D-2 receptors in the caudate-putamen are postsynaptic on striatal neurons.
Original language | English (US) |
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Pages (from-to) | 61-68 |
Number of pages | 8 |
Journal | European Journal of Pharmacology |
Volume | 138 |
Issue number | 1 |
DOIs | |
State | Published - Jun 12 1987 |
Externally published | Yes |
Keywords
- 6-Hydroxydopamine
- Autoradiography
- Autoreceptors
- D-2 dopamine receptors
- Ibotenic acid
- Substantia nigra
- Sulpiride
ASJC Scopus subject areas
- Pharmacology