Donor-transmitted malignancy in a liver transplant recipient: A case report and review of literature

Brian Kim, Tinsay Woreta, Po Hung Chen, Berkeley Limketkai, Andrew Singer, Nabil Dagher, Andrew Cameron, Ming Tseh Lin, Ihab Kamel, Ahmet Gurakar

Research output: Contribution to journalReview article

Abstract

Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.

Original languageEnglish (US)
Pages (from-to)1185-1190
Number of pages6
JournalDigestive Diseases and Sciences
Volume58
Issue number5
DOIs
StatePublished - May 1 2013

Keywords

  • Donor-transmitted malignancy
  • Hepatocellular carcinoma
  • Liver transplant
  • Microsatellite analysis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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