Donor-transmitted malignancy in a liver transplant recipient: A case report and review of literature

Brian Kim, Tinsay Woreta, Po-Hung Chen, Berkeley Limketkai, Andrew Singer, Nabil Dagher, Andrew M Cameron, Ming-Tseh Lin, Ihab R Kamel, Ahmet Gurakar

Research output: Contribution to journalArticle

Abstract

Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.

Original languageEnglish (US)
Pages (from-to)1185-1190
Number of pages6
JournalDigestive Diseases and Sciences
Volume58
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Tissue Donors
Liver
Hepatocellular Carcinoma
Neoplasms
Organ Transplantation
Microsatellite Repeats
Adenocarcinoma
Transplants
Biopsy
Recurrence
Transplant Recipients
Incidence
Therapeutics
Cryptogenic Cirrhosis

Keywords

  • Donor-transmitted malignancy
  • Hepatocellular carcinoma
  • Liver transplant
  • Microsatellite analysis

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Donor-transmitted malignancy in a liver transplant recipient : A case report and review of literature. / Kim, Brian; Woreta, Tinsay; Chen, Po-Hung; Limketkai, Berkeley; Singer, Andrew; Dagher, Nabil; Cameron, Andrew M; Lin, Ming-Tseh; Kamel, Ihab R; Gurakar, Ahmet.

In: Digestive Diseases and Sciences, Vol. 58, No. 5, 05.2013, p. 1185-1190.

Research output: Contribution to journalArticle

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