Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer

Dennis F. Habig, Justine L. Gaspari, Parvez M. Lokhandwala, Ronald E. Domen, Catherine S. Abendroth, Zakiyah Kadry, Nasrollah Ghahramani, Riaz Ali Shah, Ashokkumar Jain, Hiroko Shike

Research output: Contribution to journalArticle

Abstract

The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported. We reviewed 360 post-kidney transplant recipients (transplant: 2002-2013; follow-up: 5.6. ±. 3.3. years). DQ DSA was detected in 46 of 57 patients who developed DSA. DSA specificity was consistent with donor mismatched DQ trans-heterodimers in three patients: DQ2.5 (DQB1*02, DQA1*05), DQ2.3 (DQB1*02, DQA1*03), and DQ4.3 (DQB1*04, DQA1*03). Two of them eventually lost grafts (2 and 5. years later) with allograft nephropathy. In conclusion, post-transplant patients may develop DSA to donor DQ trans-heterodimers. Further studies are warranted to determine the clinical significance of such DSAs.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalHuman Immunology
Volume76
Issue number8
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Antibody-mediated rejection
  • C1q assay
  • Kidney transplantation
  • Solid phase assay

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Habig, D. F., Gaspari, J. L., Lokhandwala, P. M., Domen, R. E., Abendroth, C. S., Kadry, Z., Ghahramani, N., Shah, R. A., Jain, A., & Shike, H. (2015). Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer. Human Immunology, 76(8), 587-590. https://doi.org/10.1016/j.humimm.2015.09.004