Abstract
The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported. We reviewed 360 post-kidney transplant recipients (transplant: 2002-2013; follow-up: 5.6. ±. 3.3. years). DQ DSA was detected in 46 of 57 patients who developed DSA. DSA specificity was consistent with donor mismatched DQ trans-heterodimers in three patients: DQ2.5 (DQB1*02, DQA1*05), DQ2.3 (DQB1*02, DQA1*03), and DQ4.3 (DQB1*04, DQA1*03). Two of them eventually lost grafts (2 and 5. years later) with allograft nephropathy. In conclusion, post-transplant patients may develop DSA to donor DQ trans-heterodimers. Further studies are warranted to determine the clinical significance of such DSAs.
Original language | English (US) |
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Pages (from-to) | 587-590 |
Number of pages | 4 |
Journal | Human Immunology |
Volume | 76 |
Issue number | 8 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Antibody-mediated rejection
- C1q assay
- Kidney transplantation
- Solid phase assay
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology