TY - JOUR
T1 - Donor oocytes are associated with preterm birth when compared to fresh autologous in vitro fertilization cycles in singleton pregnancies
AU - Dude, Annie M.
AU - Yeh, Jason S.
AU - Muasher, Suheil J.
N1 - Publisher Copyright:
© 2016 American Society for Reproductive Medicine
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objective To use a national registry to examine the role of oocyte donation on pregnancy outcomes in singleton pregnancies. Design Retrospective cohort. Setting Not applicable. Patient(s) Women undergoing autologous cycles and donor oocyte recipients in the United States from 2008–2010. Intervention(s) None. Main Outcome Measure(s) Preterm delivery, birth weight <2,500 g, small for gestational age birthweight, perinatal death. Result(s) The rates of preterm delivery and low birthweight for all members of this cohort were higher than the US national average. Pregnancies resulting from oocyte donation were significantly more likely to end before 34 weeks' and 37 weeks' gestation (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] = 1.03–1.64 for 34 weeks' gestation, adjusted OR = 1.28, 95% CI = 1.12–1.46 for 37 weeks' gestation), and to result in infants weighing <2,500 g (adjusted OR = 1.21, 95% CI = 1.02–1.44). However, once gestational age at delivery is accounted for, these infants are actually at decreased risk of having a small for gestational age birthweight (adjusted OR = 0.72, 95% CI = 0.58–0.89) and of perinatal death (adjusted OR = 0.29, 95% CI = 0.09–0.94). Conclusion(s) Data from a national cohort indicate that donor oocyte recipients are more likely to deliver preterm when compared with autologous patients. The effect of donor oocyte donation on birthweight is likely a function of an increased rate of preterm delivery among this population.
AB - Objective To use a national registry to examine the role of oocyte donation on pregnancy outcomes in singleton pregnancies. Design Retrospective cohort. Setting Not applicable. Patient(s) Women undergoing autologous cycles and donor oocyte recipients in the United States from 2008–2010. Intervention(s) None. Main Outcome Measure(s) Preterm delivery, birth weight <2,500 g, small for gestational age birthweight, perinatal death. Result(s) The rates of preterm delivery and low birthweight for all members of this cohort were higher than the US national average. Pregnancies resulting from oocyte donation were significantly more likely to end before 34 weeks' and 37 weeks' gestation (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] = 1.03–1.64 for 34 weeks' gestation, adjusted OR = 1.28, 95% CI = 1.12–1.46 for 37 weeks' gestation), and to result in infants weighing <2,500 g (adjusted OR = 1.21, 95% CI = 1.02–1.44). However, once gestational age at delivery is accounted for, these infants are actually at decreased risk of having a small for gestational age birthweight (adjusted OR = 0.72, 95% CI = 0.58–0.89) and of perinatal death (adjusted OR = 0.29, 95% CI = 0.09–0.94). Conclusion(s) Data from a national cohort indicate that donor oocyte recipients are more likely to deliver preterm when compared with autologous patients. The effect of donor oocyte donation on birthweight is likely a function of an increased rate of preterm delivery among this population.
KW - Donor oocytes
KW - low birth weight
KW - perinatal death
KW - preterm birth
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U2 - 10.1016/j.fertnstert.2016.05.029
DO - 10.1016/j.fertnstert.2016.05.029
M3 - Article
C2 - 27343953
AN - SCOPUS:84978380213
SN - 0015-0282
VL - 106
SP - 660
EP - 665
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -