Donor modification leads to prolonged survival of limb allografts

W P Andrew Lee, P. E M Butler, M. A. Randolph, M. J. Yaremchuk

Research output: Contribution to journalArticle

Abstract

Chronic immunosuppression is essential for maintaining human hand transplant survival because composite tissue allografts are as susceptible to rejection as visceral organ allografts. Limb allografts comprise different types of tissues with varying antigenicities, and the immuno-suppressive doses required for these allografts are as high or higher than those required for solid organ allotransplantation. In particular, bone marrow is an early target of the host immune response. This study reports on donor limb modification of the marrow compartment leading to prolonged survival of limb allografts. Chimeric limb allografts comprising a Lewis rat vascularized allograft and Brown Norway rat bone marrow were created. These chimeric limbs were transplanted into three recipients: (1) Buffalo rats (n=12), where the chimeric limb was allogeneic for both vascular graft and bone marrow; (2) Lewis rats (n=12), where the limb was allogeneic for marrow alone; and (3) Brown Norway rats (n=12), where the limb was allogeneic for graft alone. This study found that Brown Norway recipients elicited significantly reduced cell-mediated and humoral immune responses in comparison with the Buffalo and Lewis recipients (p

Original languageEnglish (US)
Pages (from-to)1235-1241
Number of pages7
JournalPlastic and Reconstructive Surgery
Volume108
Issue number5
StatePublished - 2001
Externally publishedYes

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Allografts
Extremities
Bone Marrow
Buffaloes
Transplants
Composite Tissue Allografts
Norway
Humoral Immunity
Immunosuppression
Blood Vessels
Hand

ASJC Scopus subject areas

  • Surgery

Cite this

Lee, W. P. A., Butler, P. E. M., Randolph, M. A., & Yaremchuk, M. J. (2001). Donor modification leads to prolonged survival of limb allografts. Plastic and Reconstructive Surgery, 108(5), 1235-1241.

Donor modification leads to prolonged survival of limb allografts. / Lee, W P Andrew; Butler, P. E M; Randolph, M. A.; Yaremchuk, M. J.

In: Plastic and Reconstructive Surgery, Vol. 108, No. 5, 2001, p. 1235-1241.

Research output: Contribution to journalArticle

Lee, WPA, Butler, PEM, Randolph, MA & Yaremchuk, MJ 2001, 'Donor modification leads to prolonged survival of limb allografts', Plastic and Reconstructive Surgery, vol. 108, no. 5, pp. 1235-1241.
Lee WPA, Butler PEM, Randolph MA, Yaremchuk MJ. Donor modification leads to prolonged survival of limb allografts. Plastic and Reconstructive Surgery. 2001;108(5):1235-1241.
Lee, W P Andrew ; Butler, P. E M ; Randolph, M. A. ; Yaremchuk, M. J. / Donor modification leads to prolonged survival of limb allografts. In: Plastic and Reconstructive Surgery. 2001 ; Vol. 108, No. 5. pp. 1235-1241.
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