Donor-derived organ transplant transmission of coccidioidomycosis

K. L. Dierberg, K. A. Marr, A. Subramanian, H. Nace, N. Desai, J. E. Locke, S. Zhang, J. Diaz, C. Chamberlain, D. Neofytos

Research output: Contribution to journalArticlepeer-review

Abstract

Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalTransplant Infectious Disease
Volume14
Issue number3
DOIs
StatePublished - Jun 2012

Keywords

  • Coccidioidomycosis
  • Fungal infection
  • Solid organ transplantation
  • Transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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