Donor core-cooling provides improved static preservation for heart-lung transplantation

C. D. Fraser, F. Tamura, H. Adachi, G. J. Kontos, J. Brawn, G. M. Hutchins, A. M. Borkon, B. A. Reitz, William A Baumgartner

Research output: Contribution to journalArticle

Abstract

Twenty-three dairy calves underwent heart-lung allotransplantation after donor organs were procured using either donor core-cooling through cardiopulmonary bypass (CPB) or pulmonary artery flush (PAF) to assess which method provides optimal graft preservation. In Groups 1 (control) and 2, donors were cooled to 15°C on CPB and organs were either immediately transplanted (Group 1) or stored in saline solution (4°C) for 4 hours (Group 2) prior to transplantation. In Group 3, donors were pretreated with prostaglandin E1 prior to PAF with modified Euro-Collins solution. Organs were stored in saline solution (4°C) for 4 hours and were then transplanted. Acute cardiopulmonary function following transplantation was assessed by the ratio of end-systolic pressure to end-systolic dimension, extravascular lung water (EVLW), lung compliance, arterial oxygenation, and lung biopsy. Cardiac function after the transplantation procedure was similar in all groups, but EVLW values and lung biopsy scores were worse after PAF. Arterial O2 tension appeared lower after PAF, but not significantly so. Core-cooling provides superior static preservation and thus improved graft function in the acute bovine model.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalAnnals of Thoracic Surgery
Volume45
Issue number3
StatePublished - 1988

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Heart-Lung Transplantation
Pulmonary Artery
Tissue Donors
Extravascular Lung Water
Transplantation
Cardiopulmonary Bypass
Sodium Chloride
Lung
Transplants
Lung Compliance
Biopsy
Alprostadil
Arterial Pressure
Blood Pressure
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Fraser, C. D., Tamura, F., Adachi, H., Kontos, G. J., Brawn, J., Hutchins, G. M., ... Baumgartner, W. A. (1988). Donor core-cooling provides improved static preservation for heart-lung transplantation. Annals of Thoracic Surgery, 45(3), 253-257.

Donor core-cooling provides improved static preservation for heart-lung transplantation. / Fraser, C. D.; Tamura, F.; Adachi, H.; Kontos, G. J.; Brawn, J.; Hutchins, G. M.; Borkon, A. M.; Reitz, B. A.; Baumgartner, William A.

In: Annals of Thoracic Surgery, Vol. 45, No. 3, 1988, p. 253-257.

Research output: Contribution to journalArticle

Fraser, CD, Tamura, F, Adachi, H, Kontos, GJ, Brawn, J, Hutchins, GM, Borkon, AM, Reitz, BA & Baumgartner, WA 1988, 'Donor core-cooling provides improved static preservation for heart-lung transplantation', Annals of Thoracic Surgery, vol. 45, no. 3, pp. 253-257.
Fraser CD, Tamura F, Adachi H, Kontos GJ, Brawn J, Hutchins GM et al. Donor core-cooling provides improved static preservation for heart-lung transplantation. Annals of Thoracic Surgery. 1988;45(3):253-257.
Fraser, C. D. ; Tamura, F. ; Adachi, H. ; Kontos, G. J. ; Brawn, J. ; Hutchins, G. M. ; Borkon, A. M. ; Reitz, B. A. ; Baumgartner, William A. / Donor core-cooling provides improved static preservation for heart-lung transplantation. In: Annals of Thoracic Surgery. 1988 ; Vol. 45, No. 3. pp. 253-257.
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