TY - JOUR
T1 - DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug
T2 - Effects of Varying Doses in Man
AU - Snyder, Solomon H.
AU - Weingartner, Herbert
AU - Faillace, Louis A.
PY - 1971/1
Y1 - 1971/1
N2 - DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated “STP.” DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel “anxious” at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the “enhanced awareness” produced by DOET was not associated with psychotomimetic or hallucinogenic actions.
AB - DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated “STP.” DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel “anxious” at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the “enhanced awareness” produced by DOET was not associated with psychotomimetic or hallucinogenic actions.
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U2 - 10.1001/archpsyc.1971.01750070052006
DO - 10.1001/archpsyc.1971.01750070052006
M3 - Article
C2 - 4923215
AN - SCOPUS:0014986808
SN - 0003-990X
VL - 24
SP - 50
EP - 55
JO - Archives of general psychiatry
JF - Archives of general psychiatry
IS - 1
ER -