Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials

Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group

Research output: Contribution to journalArticle

Abstract

We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta-analysis of data from 7 studies did not find a significant change in plasma adiponectin concentrations following vitamin D supplementation (mean difference [MD]: 4.45%, 95%CI: -3.04, 11.93, p = 0.244; Q = 2.18, I2 = 0%). In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95%CI: -0.69, 1.19; p = 0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95%CI: -0.15, 0.12; p = 0.780). Meta-analysis of data from 6 studies did not find a significant change in plasma leptin concentrations following vitamin D supplementation (MD: -4.51%, 95%CI: -25.13, 16.11, p = 0.668; Q = 6.41, I2 = 21.97%). Sensitivity analysis showed that this effect size is sensitive to one of the studies; removing it resulted in a significant reduction in plasma leptin levels (MD: -12.81%, 95%CI: -24.33, -1.30, p = 0.029). In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95%CI: -4.08, 0.23; p = 0.080). However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95%CI: 0.08, 2.02; p = 0.033). In conclusion, current data did not indicate a significant effect of vitamin D supplementation on adiponectin and leptin levels.

Original languageEnglish (US)
Pages (from-to)360-371
Number of pages12
JournalPharmacological Research
Volume107
DOIs
StatePublished - May 1 2016

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Adipokines
Vitamin D
Meta-Analysis
Randomized Controlled Trials
Leptin
Adiponectin
Placebos
Serum
Therapeutics

Keywords

  • Adiponectin
  • Leptin
  • Meta-analysis
  • Systematic review
  • Vitamin D

ASJC Scopus subject areas

  • Pharmacology

Cite this

Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. / Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

In: Pharmacological Research, Vol. 107, 01.05.2016, p. 360-371.

Research output: Contribution to journalArticle

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abstract = "We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta-analysis of data from 7 studies did not find a significant change in plasma adiponectin concentrations following vitamin D supplementation (mean difference [MD]: 4.45{\%}, 95{\%}CI: -3.04, 11.93, p = 0.244; Q = 2.18, I2 = 0{\%}). In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95{\%}CI: -0.69, 1.19; p = 0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95{\%}CI: -0.15, 0.12; p = 0.780). Meta-analysis of data from 6 studies did not find a significant change in plasma leptin concentrations following vitamin D supplementation (MD: -4.51{\%}, 95{\%}CI: -25.13, 16.11, p = 0.668; Q = 6.41, I2 = 21.97{\%}). Sensitivity analysis showed that this effect size is sensitive to one of the studies; removing it resulted in a significant reduction in plasma leptin levels (MD: -12.81{\%}, 95{\%}CI: -24.33, -1.30, p = 0.029). In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95{\%}CI: -4.08, 0.23; p = 0.080). However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95{\%}CI: 0.08, 2.02; p = 0.033). In conclusion, current data did not indicate a significant effect of vitamin D supplementation on adiponectin and leptin levels.",
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author = "{Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group} and Madalina Dinca and Serban, {Maria Corina} and Amirhossein Sahebkar and Mikhailidis, {Dimitri P.} and Toth, {Peter P.} and Seth Martin and Michael Blaha and Matthias Bl{\"u}her and Camelia Gurban and Peter Penson and Michos, {Erin Donnelly} and Hernandez, {Adrian V.} and Steven Jones and Maciej Banach",
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AU - Sahebkar, Amirhossein

AU - Mikhailidis, Dimitri P.

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AU - Martin, Seth

AU - Blaha, Michael

AU - Blüher, Matthias

AU - Gurban, Camelia

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AU - Jones, Steven

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