TY - JOUR
T1 - Does time interval between surgery and intraperitoneal chemotherapy administration in advanced ovarian cancer carry a prognostic impact? An NRG Oncology/Gynecologic Oncology Group study ancillary study
AU - Garcia-Soto, Arlene E.
AU - Java, James J.
AU - Nieves Neira, Wilberto
AU - Pearson, J. Matthew
AU - Cohn, David E.
AU - Lele, Shashikant B.
AU - Tewari, Krishnansu S.
AU - Walker, Joan L.
AU - Alvarez Secord, Angeles
AU - Armstrong, Deborah K.
AU - Copeland, Larry J.
N1 - Funding Information:
The authors report no conflicts of interest with the exception of Dr. Angeles Alvarez Secord who wishes to acknowledge that she received funds from Janssen, Clovis Oncology, Genentech and AstraZeneca. Additionally, Dr. Alvarez Secord reports research grant funding from Astellas Pharma Inc., Genentech, Amgen, Endocyte, Exelixis, Boehringer Ingelheim, Astex Pharmaceuticals Inc., Prima Biomed, Tesaro, Astra Zeneca, Eisai Morphotek, Bristol Myers Squibb and Incyte. These funds were distributed to Duke University Medical Center to support research including salary support for Dr. Secord. In the last 36 months, she has served on Advisory Boards for Janssen, Clovis Oncology, Genentech and AstraZeneca, outside the submitted work. Appendix A
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016
Y1 - 2016
N2 - Objectives To determine the relationship of the time from surgery to intraperitoneal (IP) chemotherapy (TSIC) initiation with survival of patients with stage III epithelial ovarian cancer (EOC) patients using ancillary data from cooperative group clinical trials. Methods Data from 420 patients with stage III EOC treated with IP chemotherapy under GOG-0114 and 172 were reviewed. The Cox proportional hazards model was used to evaluate independent prognostic factors and estimate their covariate-adjusted effects on PFS and OS. Results The median TSIC was 62.5 days (interquartile range 28–83). The median TSIC was longer for patients in GOG-0114 vs those in GOG-172 (83 vs 26 days, p < 0.001). TSIC was significantly associated (p = 0.049) with PFS: each 10% increase in TSIC (days) decreases the risk of progression by 3%. TSIC was not significantly associated with OS in this model. In a linear regression model, gross residual disease was significantly associated with shorter TSIC (R2 − 0.141, 95%CI − 0.217, − 0.064, p < 0.001). When only data from GOG-172 were considered, no statistical significant association was found between TSIC and PFS or OS. Conclusions In this ancillary data study, TSIC was not associated with improved OS in patients with stage III epithelial ovarian cancer. TSIC was significantly associated with PFS for the entire cohort, suggesting increase in PFS with longer TSIC. However, this was not found when only data from GOG 172 or GOG 114 were analyzed separately. Hence, the relationship between IP chemotherapy initiation and time from surgery needs to be studied further.
AB - Objectives To determine the relationship of the time from surgery to intraperitoneal (IP) chemotherapy (TSIC) initiation with survival of patients with stage III epithelial ovarian cancer (EOC) patients using ancillary data from cooperative group clinical trials. Methods Data from 420 patients with stage III EOC treated with IP chemotherapy under GOG-0114 and 172 were reviewed. The Cox proportional hazards model was used to evaluate independent prognostic factors and estimate their covariate-adjusted effects on PFS and OS. Results The median TSIC was 62.5 days (interquartile range 28–83). The median TSIC was longer for patients in GOG-0114 vs those in GOG-172 (83 vs 26 days, p < 0.001). TSIC was significantly associated (p = 0.049) with PFS: each 10% increase in TSIC (days) decreases the risk of progression by 3%. TSIC was not significantly associated with OS in this model. In a linear regression model, gross residual disease was significantly associated with shorter TSIC (R2 − 0.141, 95%CI − 0.217, − 0.064, p < 0.001). When only data from GOG-172 were considered, no statistical significant association was found between TSIC and PFS or OS. Conclusions In this ancillary data study, TSIC was not associated with improved OS in patients with stage III epithelial ovarian cancer. TSIC was significantly associated with PFS for the entire cohort, suggesting increase in PFS with longer TSIC. However, this was not found when only data from GOG 172 or GOG 114 were analyzed separately. Hence, the relationship between IP chemotherapy initiation and time from surgery needs to be studied further.
KW - NRG Oncology
KW - Ovarian cancer
KW - Time interval between surgery and IP chemo
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U2 - 10.1016/j.ygyno.2016.10.003
DO - 10.1016/j.ygyno.2016.10.003
M3 - Article
C2 - 27726923
AN - SCOPUS:84992359710
VL - 143
SP - 484
EP - 489
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 3
ER -