Does theFMR1 gene affect IVF success?

Lisa M. Pastore, Mindy Sue Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y. Maher, William G. Kearns

Research output: Contribution to journalArticle

Abstract

FMR1 CGG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide repeat length published between 2002 and December 2017. For women with CGG repeats in the normal (<45 CGG), intermediate range (45–54 CGG), or both, research supports a minimal effect on IVF outcomes, including pregnancy rates; although one study reported lower oocyte yields after IVF stimulation in women with lower CGG repeat lengths and normal ovarian reserve. Meta-analysis revealed no association within subcategories of normal repeat length (<45 CGG) and IVF pregnancy rates (summary OR 1.0, 95% CI 0.87 to 1.15). Premutation carriers (CGG 55–200) may have reduced success with IVF treatment (lower oocyte yield) than women with a normal CGG repeat length or a full mutation, although findings are inconsistent. Direct implications of the repeat length on inheritance and the risk of Fragile X syndrome have been observed. Patients may require clinical and psychological counselling, and further preimplantation genetic testing options should be considered. Thus, there are clinical and psychological counseling implications for patients and potential further patient decisions regarding preimplantation genetic testing options.

Original languageEnglish (US)
JournalReproductive BioMedicine Online
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Fragile X Syndrome
Genetic Testing
Pregnancy Rate
Oocytes
Counseling
Trinucleotide Repeat Expansion
Psychology
Genes
Primary Ovarian Insufficiency
Trinucleotide Repeats
Mutation
Ovulation Induction
Nucleic Acid Repetitive Sequences
PubMed
Fertility
Meta-Analysis
Therapeutics
Research
Ovarian Reserve

Keywords

  • Assisted reproductive technologies
  • Female infertility
  • Fertilization rate
  • FMR1
  • Fragile X syndrome
  • In vitro fertilization
  • oocyte yield

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Pastore, L. M., Christianson, M. S., McGuinness, B., Vaught, K. C., Maher, J. Y., & Kearns, W. G. (Accepted/In press). Does theFMR1 gene affect IVF success? Reproductive BioMedicine Online. https://doi.org/10.1016/j.rbmo.2018.11.009

Does theFMR1 gene affect IVF success? / Pastore, Lisa M.; Christianson, Mindy Sue; McGuinness, Bailey; Vaught, Kamaria Cayton; Maher, Jacqueline Y.; Kearns, William G.

In: Reproductive BioMedicine Online, 01.01.2019.

Research output: Contribution to journalArticle

Pastore, Lisa M. ; Christianson, Mindy Sue ; McGuinness, Bailey ; Vaught, Kamaria Cayton ; Maher, Jacqueline Y. ; Kearns, William G. / Does theFMR1 gene affect IVF success?. In: Reproductive BioMedicine Online. 2019.
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