Does the voltage dependent anion channel modulate cardiac ischemia-reperfusion injury?

Research output: Contribution to journalReview article

Abstract

The voltage dependent anion channel (VDAC) provides exchange of metabolites, anions, and cations across the outer mitochondrial membrane. VDAC provides substrates and adenine nucleotides necessary for electron transport and therefore plays a key role in regulating mitochondrial bioenergetics. VDAC has also been suggested to regulate the response to cell death signaling. Emerging data show that VDAC is regulated by protein-protein interactions as well as by post-translational modifications. This review will focus on the regulation of VDAC and its potential role in regulating cell death in cardiac ischemia-reperfusion. This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism.

Original languageEnglish (US)
Pages (from-to)1451-1456
Number of pages6
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1818
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Cardioprotection
  • Ischemia
  • Mitochondrion
  • Phosphorylation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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