Does the proteome encode organellar pH?

Christopher L. Brett; Mark Donowitz; Rajini Rao

doi:10.1016/j.febslet.2005.12.103

Does the proteome encode organellar pH?

Christopher L. Brett, Mark Donowitz, Rajini Rao

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?

Original language	English (US)
Pages (from-to)	717-719
Number of pages	3
Journal	FEBS Letters
Volume	580
Issue number	3
DOIs	https://doi.org/10.1016/j.febslet.2005.12.103
State	Published - Feb 6 2006

Keywords

Evolution
Proteome
Subcellular compartment
Yeast
pH
pI

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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@article{354a3e26bb4543c9abe5894d027d6f93,

title = "Does the proteome encode organellar pH?",

abstract = "Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?",

keywords = "Evolution, Proteome, Subcellular compartment, Yeast, pH, pI",

author = "Brett, {Christopher L.} and Mark Donowitz and Rajini Rao",

note = "Funding Information: We thank Dr. A.J. Merz (University of Washington; Seattle, WA, USA) for help with data presentation. The authors were supported by an American Heart Association predoctoral award (to C.L.B.) and by grants from the National Institutes of Diabetes Digestive and Kidney Diseases, USA (R01-DK54214 to R.R. and R01-DK26523 to M.D.).",

year = "2006",

month = feb,

day = "6",

doi = "10.1016/j.febslet.2005.12.103",

language = "English (US)",

volume = "580",

pages = "717--719",

journal = "FEBS Letters",

issn = "0014-5793",