Does the Female Advantage in Verbal Memory Contribute to Underestimating Alzheimer's Disease Pathology in Women versus Men?

Erin E. Sundermann, Anat Biegon, Leah Rubin, Richard B. Lipton, Susan Landau, Pauline M. Maki

Research output: Contribution to journalArticle

Abstract

There is a growing recognition of sex differences in Alzheimer's disease (AD). Females show an advantage over males on tests of verbal memory, which are used to diagnose AD and its precursor, amnestic mild cognitive impairment (aMCI). Women retain this advantage in aMCI despite reduced hippocampal volume and temporal lobe glucose metabolism. Here we examined whether this female advantage endures despite evidence of AD-specific pathology, cortical amyloid-β (Aβ) deposition measured with [18F]AV45 (florbetapir) positron emission tomography. Participants with normal cognition (N 304), aMCI (N 515), and AD dementia (N 175) were drawn from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Across and within diagnostic groups, we conducted linear regressions to examine the interaction of sex with cortical Aβ burden on immediate and delayed recall on the Rey Auditory Verbal Learning Test (RAVLT) adjusting for age, education, and APOE4. In the overall group, sex by cortical Aβ interaction was significant for delayed recall only. Overall, delayed recall performance was significantly better in women versus men among those with low to moderate Aβ burden, but women and men performed similarly among those with high Aβ burden. In diagnosis-stratified analyses, a significant sex by cortical Aβ interaction was observed for delayed recall in the aMCI group, but not in the normal or AD dementia groups. Thus, women maintain a verbal memory advantage over men in aMCI despite similar levels of AD pathology. Although this advantage may benefit women by delaying verbal memory impairment until more advanced pathology, it may also delay diagnosis of aMCI and treatment intervention.

Original languageEnglish (US)
Pages (from-to)947-957
Number of pages11
JournalJournal of Alzheimer's Disease
Volume56
Issue number3
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

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Alzheimer Disease
Pathology
Verbal Learning
Temporal Lobe
Short-Term Memory
Amyloid
Neuroimaging
Sex Characteristics
Positron-Emission Tomography
Cognition
Cognitive Dysfunction
Linear Models
Education
Glucose

Keywords

  • Amyloid
  • cognitive reserve
  • memory
  • positron-emission tomography
  • sex

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Does the Female Advantage in Verbal Memory Contribute to Underestimating Alzheimer's Disease Pathology in Women versus Men? / Sundermann, Erin E.; Biegon, Anat; Rubin, Leah; Lipton, Richard B.; Landau, Susan; Maki, Pauline M.

In: Journal of Alzheimer's Disease, Vol. 56, No. 3, 01.01.2017, p. 947-957.

Research output: Contribution to journalArticle

Sundermann, Erin E. ; Biegon, Anat ; Rubin, Leah ; Lipton, Richard B. ; Landau, Susan ; Maki, Pauline M. / Does the Female Advantage in Verbal Memory Contribute to Underestimating Alzheimer's Disease Pathology in Women versus Men?. In: Journal of Alzheimer's Disease. 2017 ; Vol. 56, No. 3. pp. 947-957.
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