Does the ex utero intrapartum treatment to extracorporeal membrane oxygenation procedure change morbidity outcomes for high-risk congenital diaphragmatic hernia survivors?

Hester F. Shieh, Jay M. Wilson, Catherine A. Sheils, C. Jason Smithers, Virginia S. Kharasch, Ronald E. Becker, Mollie Studley, Donna Morash, Terry L. Buchmiller

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose In high-risk congenital diaphragmatic hernia (CDH), significant barotrauma or death can occur before extracorporeal membrane oxygenation (ECMO) can be initiated. We previously examined ex utero intrapartum treatment (EXIT)-to-ECMO in our most severe CDH patients, but demonstrated no survival advantage. We now report morbidity outcomes in survivors of this high-risk cohort to determine whether EXIT-to-ECMO conferred any benefit. Methods All CDH survivors with < 15% predicted lung volume (PPLV) from September 1999 to December 2010 were included. We recorded prenatal imaging, defect size, and pulmonary, nutritional, cardiac, and neurodevelopmental outcomes. Results Seventeen survivors (8 EXIT-to-ECMO, 9 non-EXIT) had an average PPLV of 11.7%. Eight of 9 non-EXIT received ECMO within 2 days. There were no significant defect size differences between groups, mostly left-sided (13/17) and type D (12/17). Average follow-up was 6.7 years (0–13 years). There were no statistically significant differences in outcomes, including supplemental oxygen, diuretics, gastrostomy, weight-for-age Z scores, fundoplication, pulmonary hypertension, stroke or intracranial hemorrhage rate, CDH recurrence, and reoperation. No survivor in our cohort was neurologically devastated. All had mild motor and/or speech delay, which improved in most. Conclusions In this pilot series of severe CDH survivors, EXIT-to-ECMO confers neither significant survival nor long-term morbidity benefit. Level of evidence Level III treatment study.

Original languageEnglish (US)
Pages (from-to)22-25
Number of pages4
JournalJournal of pediatric surgery
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • CDH morbidity
  • Congenital diaphragmatic hernia
  • Ex utero intrapartum treatment
  • Extracorporeal membrane oxygenation

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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