Does plastic surgical consultation improve the outcome of patients undergoing radical vulvectomy for squamous cell carcinoma of the vulva?

Emeline M. Aviki, Katharine M. Esselen, Sara M. Barcia, Marisa R. Nucci, Neil S. Horowitz, Colleen M. Feltmate, Ross S. Berkowitz, Dennis G. Orgill, Akila N. Viswanathan, Michael G. Muto

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objectives. To analyze margin status and prognostic factors for complications in patients undergoing vulvectomy for invasive squamous cell cancer (iSCC) with and without plastic-assisted closure. Methods. Demographic and clinical data were collected on 94 patientswith iSCCwho underwent vulvectomy between 2004 and 2013. All pathology slides were re-reviewed by two gynecologic pathologists. Data were analyzed using XLSTAT-Pro v2014.2.02. Results. Of 88 eligible patients, 15 (17%) had plastic-assisted vulvar closure and 73 (83%) did not. There were significantly more patients in the plastics groupwith recurrent disease (53% v 10%) and history radiation therapy prior to surgery (40% versus 5%). Plastic-assisted closure was associated with larger tumors (3.73 cm versus 2.03 cm, p < 0.01) and a higher frequency of adequate margins (53% versus 29%, p = 0.06). For tumors ≥3.0 cm, plastic-assisted closure was significantly associated with adequate margins (44% versus 6%, p = 0.03). Prior radiation usewas associatedwith plastic-assisted closure, larger tumors, older age, and recurrent disease. Complications occurred in 36 patients (41%) and significantly more occurred in those with plastic-assisted closure (67% versus 36%, p=0.04). Onmultivariate analysis including age, tumor size, recurrent disease, plasticassisted closure, and history of radiation, only history of radiation therapy was a significant predictor of complications (OR = 17, 95%CI 2.05-141.35; p = 0.01). Conclusions. Plastic-assisted vulvectomy closure was more often utilized in cases involving past radiation therapy and larger tumors. Plastic-assisted closure significantly increased the frequency of adequate margins in tumors ≥3 cm and did not impact complications.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalGynecologic oncology
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes


  • Complications
  • Plastics surgery
  • Squamous cell cancer
  • Tumor margins
  • Vulvar cancer
  • Vulvectomy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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