Does oxidative stress contribute to adverse outcomes in HIV-associated TB?

Wing Wai Yew, Denise P. Chan, Amit Singhal, Ying Zhang, Shui Shan Lee

Research output: Contribution to journalArticle

Abstract

In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients.

Original languageEnglish (US)
Pages (from-to)1117-1120
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume73
Issue number5
DOIs
StatePublished - May 1 2018

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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