TY - JOUR
T1 - Does malnutrition have a genetic component?
AU - Duggal, Priya
AU - Petri, William A.
N1 - Funding Information:
Work in the authors’ laboratories was supported by National Institutes of Health grant R01AI043596, the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases at Johns Hopkins University, and the Bill and Melinda Gates Foundation. We thank our many colleagues in the PROVIDE study for insights into the pathogenesis and consequences of malnutrition, as well as the families who participate in our longitudinal studies in Bangladesh.
Publisher Copyright:
Copyright © 2018 by Annual Reviews. All rights reserved.
PY - 2018/8/31
Y1 - 2018/8/31
N2 - Malnutrition is a complex disorder, defined by an imbalance, excess, or deficiency of nutrient intake. The visible signs of malnutrition are stunted growth and wasting, but malnourished children are also more likely to have delays in neurocognitive development, vaccine failure, and susceptibility to infection. Despite malnutrition being a major global health problem, we do not yet understand the pathogenesis of this complex disorder. Although lack of food is a major contributor to childhood malnutrition, it is not the sole cause. The mother's prenatal nutritional status, enteric infections, and intestinal inflammation also contribute to the risk of childhood malnutrition and recovery. Here, we discuss another potential risk factor, host and maternal genetics, that may play a role in the risk of malnutrition via several biological pathways. Understanding the genetic risks of malnutrition may help to identify ideal targets for intervention and treatment of malnutrition.
AB - Malnutrition is a complex disorder, defined by an imbalance, excess, or deficiency of nutrient intake. The visible signs of malnutrition are stunted growth and wasting, but malnourished children are also more likely to have delays in neurocognitive development, vaccine failure, and susceptibility to infection. Despite malnutrition being a major global health problem, we do not yet understand the pathogenesis of this complex disorder. Although lack of food is a major contributor to childhood malnutrition, it is not the sole cause. The mother's prenatal nutritional status, enteric infections, and intestinal inflammation also contribute to the risk of childhood malnutrition and recovery. Here, we discuss another potential risk factor, host and maternal genetics, that may play a role in the risk of malnutrition via several biological pathways. Understanding the genetic risks of malnutrition may help to identify ideal targets for intervention and treatment of malnutrition.
KW - malnutrition
KW - stunting
KW - underweight
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U2 - 10.1146/annurev-genom-083117-021340
DO - 10.1146/annurev-genom-083117-021340
M3 - Review article
C2 - 29874104
AN - SCOPUS:85053420341
SN - 1527-8204
VL - 19
SP - 247
EP - 262
JO - Annual Review of Genomics and Human Genetics
JF - Annual Review of Genomics and Human Genetics
ER -