Abstract
Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.
Original language | English (US) |
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Pages (from-to) | 7969-7970 |
Number of pages | 2 |
Journal | Clinical Cancer Research |
Volume | 14 |
Issue number | 24 |
DOIs |
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State | Published - Dec 15 2008 |
ASJC Scopus subject areas
- Oncology
- Cancer Research