Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

Gregg L. Semenza

doi:10.1158/1078-0432.CCR-08-2417

Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.

Original language	English (US)
Pages (from-to)	7969-7970
Number of pages	2
Journal	Clinical Cancer Research
Volume	14
Issue number	24
DOIs	https://doi.org/10.1158/1078-0432.CCR-08-2417
State	Published - Dec 15 2008

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-08-2417

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@article{06d2cce0f87c4663a724eef501c632a4,

title = "Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?",

abstract = "Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.",

author = "Semenza, {Gregg L.}",

year = "2008",

month = dec,

day = "15",

doi = "10.1158/1078-0432.CCR-08-2417",

language = "English (US)",

volume = "14",

pages = "7969--7970",

journal = "Clinical Cancer Research",

issn = "1078-0432",