Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

Gregg L Semenza

Research output: Contribution to journal › Article

Abstract

Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.

Original languageEnglish (US)
Pages (from-to)7969-7970
Number of pages2
JournalClinical Cancer Research
Volume14
Issue number24
DOIs
StatePublished - Dec 15 2008

Fingerprint

Hypoxia-Inducible Factor 1
Colonic Neoplasms
Neoplasm Metastasis
Cell Hypoxia
Basement Membrane
Epithelial Cells
Gene Expression
Hypoxia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells? / Semenza, Gregg L.

In: Clinical Cancer Research, Vol. 14, No. 24, 15.12.2008, p. 7969-7970.

Research output: Contribution to journal › Article

Semenza, GL 2008, 'Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?', Clinical Cancer Research, vol. 14, no. 24, pp. 7969-7970. https://doi.org/10.1158/1078-0432.CCR-08-2417
Semenza GL. Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells? Clinical Cancer Research. 2008 Dec 15;14(24):7969-7970. https://doi.org/10.1158/1078-0432.CCR-08-2417
Semenza, Gregg L. / Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?. In: Clinical Cancer Research. 2008 ; Vol. 14, No. 24. pp. 7969-7970.
@article{06d2cce0f87c4663a724eef501c632a4,
title = "Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?",
abstract = "Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.",
author = "Semenza, {Gregg L}",
year = "2008",
month = "12",
day = "15",
doi = "10.1158/1078-0432.CCR-08-2417",
language = "English (US)",
volume = "14",
pages = "7969--7970",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "24",

}

TY - JOUR

T1 - Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

AU - Semenza, Gregg L

PY - 2008/12/15

Y1 - 2008/12/15

N2 - Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.

AB - Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.

UR - http://www.scopus.com/inward/record.url?scp=58149356256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149356256&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-08-2417

DO - 10.1158/1078-0432.CCR-08-2417

M3 - Article

C2 - 19088010

AN - SCOPUS:58149356256

VL - 14

SP - 7969

EP - 7970

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 24

ER -

Access to Document