Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

Research output: Contribution to journalArticle

Abstract

Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.

Original languageEnglish (US)
Pages (from-to)7969-7970
Number of pages2
JournalClinical Cancer Research
Volume14
Issue number24
DOIs
StatePublished - Dec 15 2008

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Hypoxia-Inducible Factor 1
Colonic Neoplasms
Neoplasm Metastasis
Cell Hypoxia
Basement Membrane
Epithelial Cells
Gene Expression
Hypoxia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells? / Semenza, Gregg L.

In: Clinical Cancer Research, Vol. 14, No. 24, 15.12.2008, p. 7969-7970.

Research output: Contribution to journalArticle

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