TY - JOUR
T1 - Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
AU - Semenza, Gregg L.
PY - 2008/12/15
Y1 - 2008/12/15
N2 - Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.
AB - Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.
UR - http://www.scopus.com/inward/record.url?scp=58149356256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149356256&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-08-2417
DO - 10.1158/1078-0432.CCR-08-2417
M3 - Comment/debate
C2 - 19088010
AN - SCOPUS:58149356256
VL - 14
SP - 7969
EP - 7970
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 24
ER -