Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

Lluis Palenzuela; Noah M. Hahn; Robert P. Nelson; Janet N. Arno; Carol Schobert; Robert Bethel; Lisa A. Ostrowski; Manjuli R. Sharma; Partha P. Datta; Rajendra K. Agrawal; Jennifer E. Schwartz; Michio Hirano

doi:10.1086/430441

Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

Lluis Palenzuela, Noah M. Hahn, Robert P. Nelson, Janet N. Arno, Carol Schobert, Robert Bethel, Lisa A. Ostrowski, Manjuli R. Sharma, Partha P. Datta, Rajendra K. Agrawal, Jennifer E. Schwartz, Michio Hirano

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

Original language	English (US)
Pages (from-to)	e113-116
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	40
Issue number	12
DOIs	https://doi.org/10.1086/430441
State	Published - Jun 15 2005
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1086/430441

Cite this

Palenzuela, L., Hahn, N. M., Nelson, R. P., Arno, J. N., Schobert, C., Bethel, R., Ostrowski, L. A., Sharma, M. R., Datta, P. P., Agrawal, R. K., Schwartz, J. E., & Hirano, M. (2005). Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 40(12), e113-116. https://doi.org/10.1086/430441

Palenzuela, L, Hahn, NM, Nelson, RP, Arno, JN, Schobert, C, Bethel, R, Ostrowski, LA, Sharma, MR, Datta, PP, Agrawal, RK, Schwartz, JE & Hirano, M 2005, 'Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 40, no. 12, pp. e113-116. https://doi.org/10.1086/430441

@article{8b2e3b3e8b4a4218ada55469200f1665,

title = "Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?",

abstract = "Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.",

author = "Lluis Palenzuela and Hahn, {Noah M.} and Nelson, {Robert P.} and Arno, {Janet N.} and Carol Schobert and Robert Bethel and Ostrowski, {Lisa A.} and Sharma, {Manjuli R.} and Datta, {Partha P.} and Agrawal, {Rajendra K.} and Schwartz, {Jennifer E.} and Michio Hirano",

year = "2005",

month = jun,

day = "15",

doi = "10.1086/430441",

language = "English (US)",

volume = "40",

pages = "e113--116",

journal = "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",

issn = "1058-4838",