Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

Lluis Palenzuela, Noah M. Hahn, Robert P. Nelson, Janet N. Arno, Carol Schobert, Robert Bethel, Lisa A. Ostrowski, Manjuli R. Sharma, Partha P. Datta, Rajendra K. Agrawal, Jennifer E. Schwartz, Michio Hirano

Research output: Contribution to journalArticlepeer-review

Abstract

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

Original languageEnglish (US)
Pages (from-to)e113-116
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume40
Issue number12
DOIs
StatePublished - Jun 15 2005
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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