Does hypoxia affect intensive care unit delirium or long-term cognitive impairment after multiple trauma without intracranial hemorrhage?

Oscar D. Guillamondegui, Justin E. Richards, E. Wesley Ely, James C. Jackson, Kristin Archer-Swygert, Patrick R. Norris, William T. Obremskey

Research output: Contribution to journalArticle

Abstract

Background: Within the traumatic brain injury population, outcomes are affected by hypoxic events in the early injury period. Previous work shows a high prevalence of cognitive deficits in patients with multiple injuries who do not have intracranial hemorrhage identified on admission head computed tomography scan. We hypothesize that intensive care unit (ICU) delirium and long-term cognitive impairment (LTCI) are more likely in patients who have a hypoxic event within the first 48 hours of ICU admission. Methods: A total of 173 patients with multiple injuries (Injury Severity Score [ISS] >15) who presented to a Level I trauma center from July 2006 to July 2007 were enrolled in a study on long-term cognitive deficit. Ninety-seven patients required ICU management and all had continuous oxygen saturation data collected. The Confusion Assessment Method for the ICU was collected twice a day on all patients in ICU. Of the total enrolled population, 108 (62%) were evaluated 12 months after discharge by neuropsychological tests. Cognitive impairment was defined as having 2 neuropsychological test scores, 1.5 standard deviations below the mean or 1 neuropsychological test score, and 2 standard deviations below the mean. Demographic data, ISS, initial 24-hour blood requirements, presence of hypoxia (SpO2

Original languageEnglish (US)
Pages (from-to)910-915
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume70
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Delirium
Intracranial Hemorrhages
Multiple Trauma
Intensive Care Units
Neuropsychological Tests
Injury Severity Score
Confusion
Trauma Centers
Population
Head
Tomography
Demography
Cognitive Dysfunction
Hypoxia
Oxygen
Wounds and Injuries

Keywords

  • Cognitive impairment
  • Delirium
  • Hypoxia
  • Traumatic brain injury

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Does hypoxia affect intensive care unit delirium or long-term cognitive impairment after multiple trauma without intracranial hemorrhage? / Guillamondegui, Oscar D.; Richards, Justin E.; Ely, E. Wesley; Jackson, James C.; Archer-Swygert, Kristin; Norris, Patrick R.; Obremskey, William T.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 70, No. 4, 04.2011, p. 910-915.

Research output: Contribution to journalArticle

Guillamondegui, Oscar D. ; Richards, Justin E. ; Ely, E. Wesley ; Jackson, James C. ; Archer-Swygert, Kristin ; Norris, Patrick R. ; Obremskey, William T. / Does hypoxia affect intensive care unit delirium or long-term cognitive impairment after multiple trauma without intracranial hemorrhage?. In: Journal of Trauma - Injury, Infection and Critical Care. 2011 ; Vol. 70, No. 4. pp. 910-915.
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