Does HIV infection promote early kidney injury in women?

Vasantha Jotwani, Rebecca Scherzer, Alison Gump Abraham, Michelle M. Estrella, Michael Bennett, Prasad Devarajan, Kathryn Anastos, Mardge H. Cohen, Marek Nowicki, Anjali Sharma, Mary Young, Phyllis C. Tien, Carl Grunfeld, Chirag Parikh, Michael G. Shlipak

Research output: Contribution to journalArticle

Abstract

Background: In HIV-infected women, urine concentrations of novel tubulointerstitial injury markers, interleukin-18 (IL-18) and kidney injury marker-1 (KIM-1), are associated with kidney function decline and all-cause mortality. We hypothesized that HIV-infected individuals with preserved kidney filtration function would have more extensive kidney injury, as determined by urine injury markers, compared to the uninfected controls, and that risk factors for tubulointerstitial injury would differ from risk factors for albuminuria. Methods: In this cross-sectional study, we compared urine concentrations of IL-18, KIM-1 and albumin-to-creatinine ratio (ACR) in 908 HIV-infected and 289 HIV-uninfected women enrolled in the Women's Interagency HIV Study, utilizing stored urine specimens from visits between 1999 and 2000. Results: After multivariate-adjusted linear regression analysis, mean urine concentrations were higher in HIV-infected individuals by 38% for IL-18 (P

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalAntiviral Therapy
Volume19
Issue number1
DOIs
StatePublished - 2014

Fingerprint

HIV Infections
HIV
Kidney
Interleukin-18
Urine
Wounds and Injuries
Albuminuria
Albumins
Linear Models
Creatinine
Cross-Sectional Studies
Regression Analysis
Mortality

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Jotwani, V., Scherzer, R., Abraham, A. G., Estrella, M. M., Bennett, M., Devarajan, P., ... Shlipak, M. G. (2014). Does HIV infection promote early kidney injury in women? Antiviral Therapy, 19(1), 79-87. https://doi.org/10.3851/IMP2677

Does HIV infection promote early kidney injury in women? / Jotwani, Vasantha; Scherzer, Rebecca; Abraham, Alison Gump; Estrella, Michelle M.; Bennett, Michael; Devarajan, Prasad; Anastos, Kathryn; Cohen, Mardge H.; Nowicki, Marek; Sharma, Anjali; Young, Mary; Tien, Phyllis C.; Grunfeld, Carl; Parikh, Chirag; Shlipak, Michael G.

In: Antiviral Therapy, Vol. 19, No. 1, 2014, p. 79-87.

Research output: Contribution to journalArticle

Jotwani, V, Scherzer, R, Abraham, AG, Estrella, MM, Bennett, M, Devarajan, P, Anastos, K, Cohen, MH, Nowicki, M, Sharma, A, Young, M, Tien, PC, Grunfeld, C, Parikh, C & Shlipak, MG 2014, 'Does HIV infection promote early kidney injury in women?', Antiviral Therapy, vol. 19, no. 1, pp. 79-87. https://doi.org/10.3851/IMP2677
Jotwani V, Scherzer R, Abraham AG, Estrella MM, Bennett M, Devarajan P et al. Does HIV infection promote early kidney injury in women? Antiviral Therapy. 2014;19(1):79-87. https://doi.org/10.3851/IMP2677
Jotwani, Vasantha ; Scherzer, Rebecca ; Abraham, Alison Gump ; Estrella, Michelle M. ; Bennett, Michael ; Devarajan, Prasad ; Anastos, Kathryn ; Cohen, Mardge H. ; Nowicki, Marek ; Sharma, Anjali ; Young, Mary ; Tien, Phyllis C. ; Grunfeld, Carl ; Parikh, Chirag ; Shlipak, Michael G. / Does HIV infection promote early kidney injury in women?. In: Antiviral Therapy. 2014 ; Vol. 19, No. 1. pp. 79-87.
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