Does gender have an influence on platelet function and the efficacy of oral antiplatelet therapy?

The underlying pathophysiology of ischemic complications during acute coronary syndrome involves thrombus generation at sites of plaque rupture and endothelial erosion, in which platelet activation and aggregation play major roles. This review discusses whether there are intrinsic differences in thrombogenicity between genders. In trials of acute coronary syndromes with dual antiplatelet therapy strategies, women tend to experience more ischemic events. Controversy exists surrounding the protective role of estrogens in the premenopausal woman. In vitro studies support the attenuation of platelet function by estrogen. Sufficient data support the presence of gender differences in thrombogenicity to promote further investigation in this area.