Does function follow form? Methods to fuse structural and functional brain images show decreased linkage in schizophrenia

Andrew M. Michael, Stefi A. Baum, Tonya White, Oguz Demirci, Nancy C. Andreasen, Judith M. Segall, Rex E. Jung, Godfrey Pearlson, Vince P. Clark, Randy L. Gollub, S. Charles Schulz, Joshua L. Roffman, Kelvin O. Lim, Beng Choon Ho, H. Jeremy Bockholt, Vince Daniel Calhoun

Research output: Contribution to journalArticle

Abstract

When both structural magnetic resonance imaging (sMRI) and functional MRI (fMRI) data are collected they are typically analyzed separately and the joint information is not examined. Techniques that examine joint information can help to find hidden traits in complex disorders such as schizophrenia. The brain is vastly interconnected, and local brain morphology may influence functional activity at distant regions. In this paper we introduce three methods to identify inter-correlations among sMRI and fMRI voxels within the whole brain. We apply these methods to examine sMRI gray matter data and fMRI data derived from an auditory sensorimotor task from a large study of schizophrenia. In Method 1 the sMRI-fMRI cross-correlation matrix is reduced to a histogram and results show that healthy controls (HC) have stronger correlations than do patients with schizophrenia (SZ). In Method 2 the spatial information of sMRI-fMRI correlations is retained. Structural regions in the cerebellum and frontal regions show more positive and more negative correlations, respectively, with functional regions in HC than in SZ. In Method 3 significant sMRI-fMRI inter-regional links are detected, with regions in the cerebellum showing more significant positive correlations with functional regions in HC relative to SZ. Results from all three methods indicate that the linkage between gray matter and functional activation is stronger in HC than SZ. The methods introduced can be easily extended to comprehensively correlate large data sets.

Original languageEnglish (US)
Pages (from-to)2626-2637
Number of pages12
JournalNeuroImage
Volume49
Issue number3
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Schizophrenia
Magnetic Resonance Imaging
Brain
Cerebellum
Joints

Keywords

  • Cross-correlation
  • Data fusion
  • Functional MRI
  • Linkage
  • Schizophrenia
  • Structural MRI

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Does function follow form? Methods to fuse structural and functional brain images show decreased linkage in schizophrenia. / Michael, Andrew M.; Baum, Stefi A.; White, Tonya; Demirci, Oguz; Andreasen, Nancy C.; Segall, Judith M.; Jung, Rex E.; Pearlson, Godfrey; Clark, Vince P.; Gollub, Randy L.; Schulz, S. Charles; Roffman, Joshua L.; Lim, Kelvin O.; Ho, Beng Choon; Bockholt, H. Jeremy; Calhoun, Vince Daniel.

In: NeuroImage, Vol. 49, No. 3, 01.02.2010, p. 2626-2637.

Research output: Contribution to journalArticle

Michael, AM, Baum, SA, White, T, Demirci, O, Andreasen, NC, Segall, JM, Jung, RE, Pearlson, G, Clark, VP, Gollub, RL, Schulz, SC, Roffman, JL, Lim, KO, Ho, BC, Bockholt, HJ & Calhoun, VD 2010, 'Does function follow form? Methods to fuse structural and functional brain images show decreased linkage in schizophrenia', NeuroImage, vol. 49, no. 3, pp. 2626-2637. https://doi.org/10.1016/j.neuroimage.2009.08.056
Michael, Andrew M. ; Baum, Stefi A. ; White, Tonya ; Demirci, Oguz ; Andreasen, Nancy C. ; Segall, Judith M. ; Jung, Rex E. ; Pearlson, Godfrey ; Clark, Vince P. ; Gollub, Randy L. ; Schulz, S. Charles ; Roffman, Joshua L. ; Lim, Kelvin O. ; Ho, Beng Choon ; Bockholt, H. Jeremy ; Calhoun, Vince Daniel. / Does function follow form? Methods to fuse structural and functional brain images show decreased linkage in schizophrenia. In: NeuroImage. 2010 ; Vol. 49, No. 3. pp. 2626-2637.
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