Does Etiology of Pancreatitis Matter? Differences in Outcomes among Patients with Post-Endoscopic Retrograde Cholangiopancreatography, Acute Biliary, and Alcoholic Pancreatitis

Ayesha Kamal, Venkata S. Akshintala, Muhammad M. Kamal, Mohammad El Zein, Sepideh Besharati, Vivek Kumbhari, Saowanee Ngamruengphong, Eun Shin, Vikesh Singh, Anthony N Kalloo, Mouen Khashab

Research output: Contribution to journalArticle


Objectives We compared outcomes of acute alcoholic pancreatitis (AAP), acute biliary pancreatitis (ABP), and post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). Methods This was a retrospective cohort study conducted at a tertiary care center between June 2007 and June 2012. Results A total of 300 (68%) patients were diagnosed with AAP, 88 (20%) with ABP, and 55 (12%) with PEP. Longer length of hospital stay (LOHS) was more common in ABP (23%) as compared with AAP (10%) and PEP (7%, P = 0.025). Pseudocyst (P = 0.048), organ failure (OF) (P = 0.01), need for interventions (P ≤ 0.001), and mortality (P = 0.002) occurred more in ABP as compared with other groups. Systemic inflammatory response syndrome was associated with LOHS of more than 10 days (P = 0.01) and multi-OF (P = 0.05). Chronic pancreatitis was associated more with pseudocyst (P < 0.001) and mortality (P = 0.03). Serum urea nitrogen of greater than 25 g/dL predicted LOHS of more than 10 days (P = 0.02), OF (P < 0.001), multi-OF (P < 0.001), and persistent OF (P < 0.001). Conclusions Acute biliary pancreatitis is a more severe disease compared with PEP and AAP. Chronic pancreatitis, systemic inflammatory response syndrome, and high serum urea nitrogen are important predictors of morbidity.

Original languageEnglish (US)
Pages (from-to)574-578
Number of pages5
Issue number4
StatePublished - Apr 1 2019



  • alcoholic pancreatitis
  • biliary pancreatitis
  • ERCP
  • organ failure
  • persistent

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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