Does donor cause of death affect the outcome of lung transplantation?

Anna Maria Ciccone, Ken C. Stewart, Bryan F. Meyers, Tracey J. Guthrie, Richard J Battafarano, Elbert P. Trulock, Joel D. Cooper, G. Alexander Patterson

Research output: Contribution to journalArticle

Abstract

Background: Accumulating evidence suggests that the donor's cause of death may influence posttransplantation allograft function. We conducted a retrospective analysis of our adult lung transplant experience to investigate the influence of donor traumatic brain injury versus nontraumatic brain injury on posttransplantation outcome. Methods: We retrospectively reviewed donor records and recipient medical charts for 500 consecutive lung transplants performed between July 1988 and December 1999. Recipient follow-up was complete, with a minimum follow-up of 1 year of survival. Results: There were 295 and 205 donors in the traumatic and nontraumatic brain injury groups, respectively. Young male donors predominated in the traumatic brain injury group. Recipients receiving donor lungs from the traumatic and nontraumatic brain injury groups did not differ by age, sex, diagnosis, type of transplant (single-lung versus double-lung) or requirement for pretransplantation mechanical ventilatory assistance. Recipients did not differ in immediate or 24-hour Pao2/inspired oxygen ratio, ventilation time, hospital stay, hospital mortality, or overall survival. Recipients of organs from donors who died of traumatic brain injury showed a higher severity and frequency of rejection episodes during the first year after transplantation. Freedoms from bronchiolitis obliterans syndrome at 5 years were 34.5% and 50.8% for recipients of organs from donors who died of traumatic and nontraumatic brain injury, respectively (P = .002). Conclusions: The cause of donor brain death does not appear to influence early results of lung transplantation. Traumatic brain injury, or some phenomenon associated with it, may predispose a transplanted lung and its recipient toward more severe early rejection episodes and subsequent development of bronchiolitis obliterans syndrome.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume123
Issue number3
DOIs
StatePublished - Mar 1 2002
Externally publishedYes

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Lung Transplantation
Cause of Death
Tissue Donors
Lung
Bronchiolitis Obliterans
Transplants
Brain Death
Survival
Hospital Mortality
Traumatic Brain Injury
Brain Injuries
Medical Records
Allografts
Ventilation
Length of Stay
Transplantation
Oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Ciccone, A. M., Stewart, K. C., Meyers, B. F., Guthrie, T. J., Battafarano, R. J., Trulock, E. P., ... Patterson, G. A. (2002). Does donor cause of death affect the outcome of lung transplantation? Journal of Thoracic and Cardiovascular Surgery, 123(3), 429-436. https://doi.org/10.1067/mtc.2002.120732

Does donor cause of death affect the outcome of lung transplantation? / Ciccone, Anna Maria; Stewart, Ken C.; Meyers, Bryan F.; Guthrie, Tracey J.; Battafarano, Richard J; Trulock, Elbert P.; Cooper, Joel D.; Patterson, G. Alexander.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 123, No. 3, 01.03.2002, p. 429-436.

Research output: Contribution to journalArticle

Ciccone, AM, Stewart, KC, Meyers, BF, Guthrie, TJ, Battafarano, RJ, Trulock, EP, Cooper, JD & Patterson, GA 2002, 'Does donor cause of death affect the outcome of lung transplantation?', Journal of Thoracic and Cardiovascular Surgery, vol. 123, no. 3, pp. 429-436. https://doi.org/10.1067/mtc.2002.120732
Ciccone, Anna Maria ; Stewart, Ken C. ; Meyers, Bryan F. ; Guthrie, Tracey J. ; Battafarano, Richard J ; Trulock, Elbert P. ; Cooper, Joel D. ; Patterson, G. Alexander. / Does donor cause of death affect the outcome of lung transplantation?. In: Journal of Thoracic and Cardiovascular Surgery. 2002 ; Vol. 123, No. 3. pp. 429-436.
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