Does DNA repair occur during somatic hypermutation?

Huseyin Saribasak, Patricia J. Gearhart

Research output: Contribution to journalReview articlepeer-review

Abstract

Activation-induced deaminase (AID) initiates a flood of DNA damage in the immunoglobulin loci, leading to abasic sites, single-strand breaks and mismatches. It is compelling that some proteins in the canonical base excision and mismatch repair pathways have been hijacked to increase mutagenesis during somatic hypermutation. Thus, the AID-induced mutagenic pathways involve a mix of DNA repair proteins and low fidelity DNA polymerases to create antibody diversity. In this review, we analyze the roles of base excision repair, mismatch repair, and mutagenesis during somatic hypermutation of rearranged variable genes. The emerging view is that faithful base excision repair occurs simultaneously with mutagenesis, whereas faithful mismatch repair is mostly absent.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalSeminars in immunology
Volume24
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • Activation-induced deaminase
  • Base excision repair
  • DNA polymerases
  • Mismatch repair

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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