Does calcium mediate the slowing of gastric emptying in primates?

J. N. Hunt, Paul R McHugh

Research output: Contribution to journalArticle

Abstract

Disodium edetate (EDTA, 1 g/l) in test meals of water slowed gastric emptying strongly in one human and in four rhesus monkeys. When the binding sites of the EDTA were loaded with calcium before it was given in the test meal, there was little effect on gastric emptying. It is suggested that EDTA takes up calcium from the "tight junctions" of the duodenal epithelium. As a result a signal is set up that slows gastric emptying. It is postulated that the anions of fatty acids produced during the digestion of triglycerides in the duodenum also slow gastric emptying by the same mechanism. We explain how fats, carbohydrates, and proteins could all slow gastric emptying by operating on the same receptor.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume243
Issue number3
StatePublished - Sep 1982
Externally publishedYes

Fingerprint

Gastric Emptying
Primates
Calcium
Edetic Acid
Meals
Tight Junctions
Macaca mulatta
Duodenum
Anions
Digestion
Triglycerides
Fatty Acids
Epithelium
Fats
Binding Sites
Carbohydrates
Water
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Does calcium mediate the slowing of gastric emptying in primates? / Hunt, J. N.; McHugh, Paul R.

In: The American journal of physiology, Vol. 243, No. 3, 09.1982.

Research output: Contribution to journalArticle

@article{b0d15a8df7544ca2ad4138663c405b28,
title = "Does calcium mediate the slowing of gastric emptying in primates?",
abstract = "Disodium edetate (EDTA, 1 g/l) in test meals of water slowed gastric emptying strongly in one human and in four rhesus monkeys. When the binding sites of the EDTA were loaded with calcium before it was given in the test meal, there was little effect on gastric emptying. It is suggested that EDTA takes up calcium from the {"}tight junctions{"} of the duodenal epithelium. As a result a signal is set up that slows gastric emptying. It is postulated that the anions of fatty acids produced during the digestion of triglycerides in the duodenum also slow gastric emptying by the same mechanism. We explain how fats, carbohydrates, and proteins could all slow gastric emptying by operating on the same receptor.",
author = "Hunt, {J. N.} and McHugh, {Paul R}",
year = "1982",
month = "9",
language = "English (US)",
volume = "243",
journal = "American Journal of Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Does calcium mediate the slowing of gastric emptying in primates?

AU - Hunt, J. N.

AU - McHugh, Paul R

PY - 1982/9

Y1 - 1982/9

N2 - Disodium edetate (EDTA, 1 g/l) in test meals of water slowed gastric emptying strongly in one human and in four rhesus monkeys. When the binding sites of the EDTA were loaded with calcium before it was given in the test meal, there was little effect on gastric emptying. It is suggested that EDTA takes up calcium from the "tight junctions" of the duodenal epithelium. As a result a signal is set up that slows gastric emptying. It is postulated that the anions of fatty acids produced during the digestion of triglycerides in the duodenum also slow gastric emptying by the same mechanism. We explain how fats, carbohydrates, and proteins could all slow gastric emptying by operating on the same receptor.

AB - Disodium edetate (EDTA, 1 g/l) in test meals of water slowed gastric emptying strongly in one human and in four rhesus monkeys. When the binding sites of the EDTA were loaded with calcium before it was given in the test meal, there was little effect on gastric emptying. It is suggested that EDTA takes up calcium from the "tight junctions" of the duodenal epithelium. As a result a signal is set up that slows gastric emptying. It is postulated that the anions of fatty acids produced during the digestion of triglycerides in the duodenum also slow gastric emptying by the same mechanism. We explain how fats, carbohydrates, and proteins could all slow gastric emptying by operating on the same receptor.

UR - http://www.scopus.com/inward/record.url?scp=0020189434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020189434&partnerID=8YFLogxK

M3 - Article

C2 - 6810711

AN - SCOPUS:0020189434

VL - 243

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 3

ER -