Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users?

Farzana Kapadia, David Vlahov, Don C. Des Jarlais, Steffanie A. Strathdee, Lawrence Ouellet, Peter Kerndt, Edward V. Morse E, Ian Williams, Richard S. Garfein

Research output: Contribution to journalArticle

Abstract

Background. Hepatitis C virus (HCV) has emerged as a major public health problem among injection drug users. In this analysis we examine whether disinfection of syringes with bleach has a potentially protective effect on anti-HCV seroconversion. Methods. We conducted a nested case-control study comparing 78 anti-HCV seroconverters with 390 persistently anti-HCV seronegative injection drug users. These data come from the Second Collaborative Injection Drug Users Study, a prospective cohort study that recruited injection drug users from five U.S. cities between 1997 and 1999. We used conditional logistic regression to determine the effect of bleach disinfection of syringes on anti-HCV seroconversion. Results. Participants who reported using bleach all the time had an odds ratio (OR) for anti-HCV seroconversion of 0.35 (95% confidence interval = 0.08-1.62), whereas those reporting bleach use only some of the time had an odds ratio of 0.76 (0.21-2.70), when compared with those reporting no bleach use. Conclusions. These results suggest that bleach disinfection of syringes, although not a substitute for use of sterile needles or cessation of injection, may help to prevent HCV infection among injection drug users.

Original languageEnglish (US)
Pages (from-to)738-741
Number of pages4
JournalEpidemiology
Volume13
Issue number6
DOIs
StatePublished - Nov 2002
Externally publishedYes

Fingerprint

Disinfection
Syringes
Hepatitis C
Drug Users
Hepacivirus
Young Adult
Injections
Infection
Odds Ratio
Virus Diseases
Needles
Case-Control Studies
Cohort Studies
Public Health
Logistic Models
Prospective Studies
Confidence Intervals
Seroconversion

Keywords

  • Hepatitis C virus
  • Injection drug use
  • Prevention

ASJC Scopus subject areas

  • Epidemiology

Cite this

Kapadia, F., Vlahov, D., Des Jarlais, D. C., Strathdee, S. A., Ouellet, L., Kerndt, P., ... Garfein, R. S. (2002). Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users? Epidemiology, 13(6), 738-741. https://doi.org/10.1097/00001648-200211000-00023

Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users? / Kapadia, Farzana; Vlahov, David; Des Jarlais, Don C.; Strathdee, Steffanie A.; Ouellet, Lawrence; Kerndt, Peter; Morse E, Edward V.; Williams, Ian; Garfein, Richard S.

In: Epidemiology, Vol. 13, No. 6, 11.2002, p. 738-741.

Research output: Contribution to journalArticle

Kapadia, F, Vlahov, D, Des Jarlais, DC, Strathdee, SA, Ouellet, L, Kerndt, P, Morse E, EV, Williams, I & Garfein, RS 2002, 'Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users?', Epidemiology, vol. 13, no. 6, pp. 738-741. https://doi.org/10.1097/00001648-200211000-00023
Kapadia, Farzana ; Vlahov, David ; Des Jarlais, Don C. ; Strathdee, Steffanie A. ; Ouellet, Lawrence ; Kerndt, Peter ; Morse E, Edward V. ; Williams, Ian ; Garfein, Richard S. / Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users?. In: Epidemiology. 2002 ; Vol. 13, No. 6. pp. 738-741.
@article{e39933fabe9f4960815f287f907b00bf,
title = "Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users?",
abstract = "Background. Hepatitis C virus (HCV) has emerged as a major public health problem among injection drug users. In this analysis we examine whether disinfection of syringes with bleach has a potentially protective effect on anti-HCV seroconversion. Methods. We conducted a nested case-control study comparing 78 anti-HCV seroconverters with 390 persistently anti-HCV seronegative injection drug users. These data come from the Second Collaborative Injection Drug Users Study, a prospective cohort study that recruited injection drug users from five U.S. cities between 1997 and 1999. We used conditional logistic regression to determine the effect of bleach disinfection of syringes on anti-HCV seroconversion. Results. Participants who reported using bleach all the time had an odds ratio (OR) for anti-HCV seroconversion of 0.35 (95{\%} confidence interval = 0.08-1.62), whereas those reporting bleach use only some of the time had an odds ratio of 0.76 (0.21-2.70), when compared with those reporting no bleach use. Conclusions. These results suggest that bleach disinfection of syringes, although not a substitute for use of sterile needles or cessation of injection, may help to prevent HCV infection among injection drug users.",
keywords = "Hepatitis C virus, Injection drug use, Prevention",
author = "Farzana Kapadia and David Vlahov and {Des Jarlais}, {Don C.} and Strathdee, {Steffanie A.} and Lawrence Ouellet and Peter Kerndt and {Morse E}, {Edward V.} and Ian Williams and Garfein, {Richard S.}",
year = "2002",
month = "11",
doi = "10.1097/00001648-200211000-00023",
language = "English (US)",
volume = "13",
pages = "738--741",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Does bleach disinfection of syringes protect against hepatitis C infection among young adult injection drug users?

AU - Kapadia, Farzana

AU - Vlahov, David

AU - Des Jarlais, Don C.

AU - Strathdee, Steffanie A.

AU - Ouellet, Lawrence

AU - Kerndt, Peter

AU - Morse E, Edward V.

AU - Williams, Ian

AU - Garfein, Richard S.

PY - 2002/11

Y1 - 2002/11

N2 - Background. Hepatitis C virus (HCV) has emerged as a major public health problem among injection drug users. In this analysis we examine whether disinfection of syringes with bleach has a potentially protective effect on anti-HCV seroconversion. Methods. We conducted a nested case-control study comparing 78 anti-HCV seroconverters with 390 persistently anti-HCV seronegative injection drug users. These data come from the Second Collaborative Injection Drug Users Study, a prospective cohort study that recruited injection drug users from five U.S. cities between 1997 and 1999. We used conditional logistic regression to determine the effect of bleach disinfection of syringes on anti-HCV seroconversion. Results. Participants who reported using bleach all the time had an odds ratio (OR) for anti-HCV seroconversion of 0.35 (95% confidence interval = 0.08-1.62), whereas those reporting bleach use only some of the time had an odds ratio of 0.76 (0.21-2.70), when compared with those reporting no bleach use. Conclusions. These results suggest that bleach disinfection of syringes, although not a substitute for use of sterile needles or cessation of injection, may help to prevent HCV infection among injection drug users.

AB - Background. Hepatitis C virus (HCV) has emerged as a major public health problem among injection drug users. In this analysis we examine whether disinfection of syringes with bleach has a potentially protective effect on anti-HCV seroconversion. Methods. We conducted a nested case-control study comparing 78 anti-HCV seroconverters with 390 persistently anti-HCV seronegative injection drug users. These data come from the Second Collaborative Injection Drug Users Study, a prospective cohort study that recruited injection drug users from five U.S. cities between 1997 and 1999. We used conditional logistic regression to determine the effect of bleach disinfection of syringes on anti-HCV seroconversion. Results. Participants who reported using bleach all the time had an odds ratio (OR) for anti-HCV seroconversion of 0.35 (95% confidence interval = 0.08-1.62), whereas those reporting bleach use only some of the time had an odds ratio of 0.76 (0.21-2.70), when compared with those reporting no bleach use. Conclusions. These results suggest that bleach disinfection of syringes, although not a substitute for use of sterile needles or cessation of injection, may help to prevent HCV infection among injection drug users.

KW - Hepatitis C virus

KW - Injection drug use

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=0036831778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036831778&partnerID=8YFLogxK

U2 - 10.1097/00001648-200211000-00023

DO - 10.1097/00001648-200211000-00023

M3 - Article

VL - 13

SP - 738

EP - 741

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 6

ER -