Abstract
As we learn more about the HIV latent reservoir, we continue to discover that the viral reservoir is more complicated than just a pool of infected resting memory CD4+ T cells in peripheral blood. Evidence increasingly points to both certain tissues and certain types of cells as potential viral reservoirs. T follicular helper cells (TFH) are prime targets of HIV infection—this creates a sanctuary for infected cells because CD8+ T cells generally do not enter lymph node follicles unless they express CXCR5, and are not as effective at killing infected CD4+ T cells as peripheral CD8+ T cells. In this review, we summarize the current state of research on TFH cell infection in peripheral lymphoid tissues and focus on the question of whether CD8+ T cell exclusion from B cell follicles is responsible, at least in part, for establishing secondary lymphoid tissue B cell follicles as an anatomic site of HIV transcription and replication.
Original language | English (US) |
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Article number | 2362 |
Journal | Frontiers in immunology |
Volume | 10 |
DOIs | |
State | Published - Oct 9 2019 |
Keywords
- B cell follicle sanctuary
- CD8+ lymphocytes
- HIV
- lymph nodes
- reservoir
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology